PTPRH

PTPRH
Identifiers
Aliases	PTPRH, R-PTP-H, SAP1, protein tyrosine phosphatase, receptor type H, protein tyrosine phosphatase receptor type H
External IDs	OMIM: 602510; MGI: 3026877; HomoloGene: 37693; GeneCards: PTPRH; OMA:PTPRH - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,209,506 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	4,607,040 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; pancreatic ductal cell; ; mucosa of transverse colon; ; gallbladder; ; mucosa of ileum; ; rectum; ; islet of Langerhans; ; oocyte; ; spleen;
	Top expressed in
	jejunum; ; ileum; ; colon; ; duodenum; ; stomach; ; striatum of neuraxis; ; superior frontal gyrus; ; cerebellar cortex; ; primary visual cortex; ; hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity; protein binding; phosphoprotein phosphatase activity; hydrolase activity;
Cellular component	cytoplasm; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; microvillus; apical plasma membrane; microvillus membrane; cell projection;
Biological process	protein dephosphorylation; dephosphorylation; apoptotic process; peptidyl-tyrosine dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	5794
	545902
	ENSG00000080031
	ENSMUSG00000035429
	Q9HD43
	E9Q0N2
	NM_001161440; NM_002842
	NM_207270
	NP_001154912; NP_002833
	NP_997153
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene.^[5]^[6]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000080031 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035429 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Matozaki T, Suzuki T, Uchida T, Inazawa J, Ariyama T, Matsuda K, Horita K, Noguchi H, Mizuno H, Sakamoto C, et al. (Feb 1994). "Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers". J Biol Chem. 269 (3): 2075–81. doi:10.1016/S0021-9258(17)42137-5. PMID 8294459.
^ ^a ^b "Entrez Gene: PTPRH protein tyrosine phosphatase, receptor type, H".

Noguchi T, Tsuda M, Takeda H, et al. (2001). "Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas". J. Biol. Chem. 276 (18): 15216–24. doi:10.1074/jbc.M007208200. PMID 11278335.
Marneros AG, Mehenni H, Reichenberger E, et al. (2001). "Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome". Cytogenet. Cell Genet. 92 (3–4): 213–6. doi:10.1159/000056905. PMID 11435690. S2CID 20187527.
Takada T, Noguchi T, Inagaki K, et al. (2002). "Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1". J. Biol. Chem. 277 (37): 34359–66. doi:10.1074/jbc.M206541200. PMID 12101188.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nagano H, Noguchi T, Inagaki K, et al. (2003). "Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma". Oncogene. 22 (30): 4656–63. doi:10.1038/sj.onc.1206588. PMID 12879010. S2CID 2707273.
Pasquali C, Curchod ML, Wälchli S, et al. (2004). "Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor". Mol. Endocrinol. 17 (11): 2228–39. doi:10.1210/me.2003-0011. PMID 12907755.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000080031 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035429 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8294459-5] Matozaki T, Suzuki T, Uchida T, Inazawa J, Ariyama T, Matsuda K, Horita K, Noguchi H, Mizuno H, Sakamoto C, et al. (Feb 1994). "Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers". J Biol Chem. 269 (3): 2075–81. doi:10.1016/S0021-9258(17)42137-5. PMID 8294459.

[entrez-6] "Entrez Gene: PTPRH protein tyrosine phosphatase, receptor type, H".

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References

Further reading