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PTP4A2

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PTP4A2
Identifiers
AliasesPTP4A2, HH13, HH7-2, HU-PP-1, OV-1, PRL-2, PRL2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b, protein tyrosine phosphatase type IVA, member 2, protein tyrosine phosphatase 4A2
External IDsOMIM: 601584; MGI: 1277117; HomoloGene: 20744; GeneCards: PTP4A2; OMA:PTP4A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001164745
NM_008974

RefSeq (protein)

NP_001158217
NP_033000

Location (UCSC)Chr 1: 31.91 – 31.94 MbChr 4: 129.71 – 129.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein tyrosine phosphatase type IVA 2 is an enzyme that in humans is encoded by the PTP4A2 gene.[5][6][7]

The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif.

This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity.

Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants that encode two distinct isoforms have been described.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184007Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028788Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhao Z, Lee CC, Monckton DG, Yazdani A, Coolbaugh MI, Li X, Bailey J, Shen Y, Caskey CT (Sep 1996). "Characterization and genomic mapping of genes and pseudogenes of a new human protein tyrosine phosphatase". Genomics. 35 (1): 172–81. doi:10.1006/geno.1996.0336. PMID 8661118.
  6. ^ Zeng Q, Hong W, Tan YH (Apr 1998). "Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1". Biochem Biophys Res Commun. 244 (2): 421–7. doi:10.1006/bbrc.1998.8291. PMID 9514946.
  7. ^ a b "Entrez Gene: PTP4A2 protein tyrosine phosphatase type IVA, member 2".

Further reading

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