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ADAMTS13 endopeptidase

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ADAMTS13 endopeptidase
Identifiers
EC no.3.4.24.87
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
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ADAMTS13 endopeptidase (EC 3.4.24.87, ADAMTS VWF cleaving metalloprotease, ADAMTS-13, ADAMTS13, vWF-cleaving protease, VWF-CP, vWF-degrading protease, Upshaw factor, von Willebrand factor cleaving protease, ADAMTS13 peptidase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

The enzyme cleaves the von Willebrand factor at bond Tyr842-Met843 within the A2 domain

This enzyme belong in the peptidase family M12.

References

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  1. ^ Fujikawa K, Suzuki H, McMullen B, Chung D (September 2001). "Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family". Blood. 98 (6): 1662–6. doi:10.1182/blood.v98.6.1662. PMID 11535495.
  2. ^ Dong JF, Moake JL, Nolasco L, Bernardo A, Arceneaux W, Shrimpton CN, Schade AJ, McIntire LV, Fujikawa K, López JA (December 2002). "ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions". Blood. 100 (12): 4033–9. doi:10.1182/blood-2002-05-1401. PMID 12393397.
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