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MMP21

From Wikipedia, the free encyclopedia
MMP21
Identifiers
AliasesMMP21, MMP-21, HTX7, matrix metallopeptidase 21
External IDsOMIM: 608416; MGI: 2664387; HomoloGene: 17519; GeneCards: MMP21; OMA:MMP21 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_147191

NM_152944
NM_001320216

RefSeq (protein)

NP_671724

NP_001307145
NP_694423

Location (UCSC)Chr 10: 125.75 – 125.78 MbChr 7: 133.28 – 133.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Matrix metalloproteinase-21 (MMP-21) is an enzyme that in humans is encoded by the MMP21 gene.[5][6]

Function

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This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154485Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030981Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Marchenko GN, Strongin AY (Mar 2001). "MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors". Gene. 265 (1–2): 87–93. doi:10.1016/S0378-1119(01)00360-2. PMID 11255011.
  6. ^ a b "Entrez Gene: MMP21 matrix metallopeptidase 21".

Further reading

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  • The MEROPS online database for peptidases and their inhibitors: M10.026