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Bacterial neuraminidase

From Wikipedia, the free encyclopedia
BNR/Asp-box repeat
Structure of a bacterial sialidase.[1]
Identifiers
SymbolBNR
PfamPF02012
Pfam clanCL0434
InterProIPR002860
SCOP21euu / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1dil​, 1dim​, 1eur​, 1eus​, 1eut​, 1euu​, 1kit​, 1mr5​, 1ms0​, 1ms1​, 1ms3​, 1ms4​, 1ms5​, 1ms8​, 1ms9​, 1mz5​, 1mz6​, 1n1s​, 1n1t​, 1n1v​, 1n1y​, 1s0i​, 1s0j​, 1sli​, 1sll​, 1sqj​, 1w0o​, 1w0p​, 1w8n​, 1w8o​, 1wcq​, 1wcs​, 2a75​, 2ags​, 2ah2​, 2ber​, 2bzd​, 2ebs​, 2fhr​, 2jkb​, 2sil​, 2sim​, 2sli​, 2vw0​, 2vw1​, 2vw2​, 3b69​, 3b7f​, 3sil​, 3sli​, 4sli

Bacterial neuraminidase is type of neuraminidase and a virulence factor for many bacteria including Bacteroides fragilis and Pseudomonas aeruginosa. Its function is to cleave a sialic acid residue off ganglioside-GM1 (a modulator of cell surface and receptor activity) turning it into asialo-GM1 to which type 4 pili (attachment factors) bind preferentially.

References

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  1. ^ Gaskell A, Crennell S, Taylor G (November 1995). "The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll". Structure. 3 (11): 1197–205. doi:10.1016/s0969-2126(01)00255-6. PMID 8591030.