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NAGA (gene)

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NAGA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNAGA, D22S674, GALB, alpha-N-acetylgalactosaminidase
External IDsOMIM: 104170; MGI: 1261422; HomoloGene: 221; GeneCards: NAGA; OMA:NAGA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000262
NM_001362848
NM_001362850

NM_008669
NM_001355546

RefSeq (protein)

NP_000253
NP_001349777
NP_001349779
NP_000253.1

NP_032695
NP_001342475

Location (UCSC)Chr 22: 42.06 – 42.07 MbChr 15: 82.21 – 82.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alpha-N-acetylgalactosaminidase is an enzyme that in humans is encoded by the NAGA gene.[5]

NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease).[5]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198951Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022453Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: NAGA N-acetylgalactosaminidase, alpha-".

Further reading

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[edit]
  • Overview of all the structural information available in the PDB for UniProt: P17050 (Human Alpha-N-acetylgalactosaminidase (NAGA)) at the PDBe-KB.