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Bothrolysin

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Bothrolysin
Identifiers
EC no.3.4.24.50
CAS no.443890-65-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

Bothrolysin (EC 3.4.24.50, Bothrops metalloendopeptidase J, J protease) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Cleavage of Gln4-His, Ser9-His and Ala14-Leu of insulin B chain and Pro-Phe of angiotensin I

This endopeptidase is present in the venom of the jararaca snake (Bothrops jararaca).

References

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  1. ^ Tanizaki MM, Zingali RB, Kawazaki H, Imajoh S, Yamazaki S, Suzuki K (1989). "Purification and some characteristics of a zinc metalloprotease from the venom of Bothrops jararaca (jararaca)". Toxicon. 27 (7): 747–55. doi:10.1016/0041-0101(89)90041-x. PMID 2781574.
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