Jump to content

Horrilysin

From Wikipedia, the free encyclopedia
Horrilysin
Identifiers
EC no.3.4.24.47
CAS no.84056-81-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Horrilysin (EC 3.4.24.47, Crotalus horridus metalloendopeptidase, hemorrhagic proteinase IV, Crotalus horridus horridus venom hemorrhagic proteinase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Cleavage of only the single bond Ala14-Leu in the insulin B chain, Ser12-Leu in the A chain, and Ile-Gly, Pro-Ala, and Ser-Trp in melittin

This endopeptidase is present in the venom of the timber rattlesnake (Crotalus horridus horridus)

References

[edit]
  1. ^ Civello DJ, Duong HL, Geren CR (February 1983). "Isolation and characterization of a hemorrhagic proteinase from timber rattlesnake venom". Biochemistry. 22 (4): 749–55. doi:10.1021/bi00273a007. PMID 6340728.
  2. ^ Civello DJ, Moran JB, Geren CR (February 1983). "Substrate specificity of a hemorrhagic proteinase from timber rattlesnake venom". Biochemistry. 22 (4): 755–62. doi:10.1021/bi00273a008. PMID 6340729.
[edit]