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Mannosylglycoprotein endo-beta-mannosidase

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Mannosylglycoprotein endo-beta-mannosidase
Identifiers
EC no.3.2.1.152
CAS no.141176-95-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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Mannosylglycoprotein endo-beta-mannosidase (EC 3.2.1.152, endo-beta-mannosidase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction:

Hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl sequences

The substrate group is a substituent on N-4 of an asparagine residue in the glycoprotein.

References

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  1. ^ Ishimizu T, Sasaki A, Okutani S, Maeda M, Yamagishi M, Hase S (September 2004). "Endo-beta-mannosidase, a plant enzyme acting on N-glycan: purification, molecular cloning, and characterization". The Journal of Biological Chemistry. 279 (37): 38555–62. doi:10.1074/jbc.m406886200. PMID 15247239.
  2. ^ Sasaki A, Yamagishi M, Mega T, Norioka S, Natsuka S, Hase S (February 1999). "Partial purification and characterization of a novel endo-beta-mannosidase acting on N-linked sugar chains from Lilium longflorum thumb". Journal of Biochemistry. 125 (2): 363–7. doi:10.1093/oxfordjournals.jbchem.a022295. PMID 9990135.
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