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Trimerelysin II

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Trimerelysin II
Identifiers
EC no.3.4.24.53
CAS no.151125-15-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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Trimerelysin II (EC 3.4.24.53, Trimeresurus metalloendopeptidase II, proteinase H2, H2-proteinase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Cleavage of Asn3-Gln, His10-Leu and Ala14-Leu in the insulin B chain, and the bond Z-Gly-Pro-Leu-Gly-Pro in a small molecule substrate of microbial collagenase

This endopeptidase is present in the venom of the habu snake (Trimeresurus flavoviridis).

References

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  1. ^ Takahashi T, Ohsaka A (February 1970). "Purification and characterization of a proteinase in the venom of Trimeresurus flavoviridis. Complete separation of the enzyme from hemorrhagic activity". Biochimica et Biophysica Acta (BBA) - Enzymology. 198 (2): 293–307. doi:10.1016/0005-2744(70)90062-8. PMID 4984550.
  2. ^ Takeya H, Arakawa M, Miyata T, Iwanaga S, Omori-Satoh T (July 1989). "Primary structure of H2-proteinase, a non-hemorrhagic metalloproteinase, isolated from the venom of the habu snake, Trimeresurus flavoviridis". Journal of Biochemistry. 106 (1): 151–7. doi:10.1093/oxfordjournals.jbchem.a122805. PMID 2777746.
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