Homospermidin sintaza (spermidin-specifična)
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| Homospermidin sintaza (spermidin-specifična) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.45 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Homospermidin sintaza (spermidin-specifična) (EC 2.5.1.45) je enzim sa sistematskim imenom spermidin:putrescin 4-aminobutiltransferaza (formira propan-1,3-diamin).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
Reakcija ovog enzima se odvija u tri koraka, pri čemu su neki od intermedijera vezani za enzim: NAD+-zavisna dehidrogenacija putrescina, transfer 4-aminobutilidenske grupe sa dehidroputrescina na drugi molekul putrescina i redukcija iminskog intermedijera čime se formira homospermidin.
- ↑ Böttcher, F., Ober, D. and Hartmann, T. (1994). „Biosynthesis of pyrrolizidine alkaloids: putrescine and spermidine are essential substrates of enzymatic homospermidine formation”. Can. J. Chem. 72: 80-85.
- ↑ Ober, D. and Hartmann, T. (1999). „Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase”. Proc. Natl. Acad. Sci. USA 96: 14777-14782. PMID 10611289.
- ↑ Ober, D., Harms, R. and Hartmann, T. (2000). „Cloning and expression of homospermidine synthase from Senecio vulgaris: a revision”. Phytochemistry 55: 311-316.
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