CD47

CD47
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2JJS, 2JJT, 2VSC, 4CMM, 4KJY, 5IWL
Dynodwyr
Cyfenwau	CD47, IAP, MER6, OA3, CD47 molecule
Dynodwyr allanol	OMIM: 601028 HomoloGene: 1346 GeneCards: CD47
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• thrombospondin receptor activity; • GO:0001948, GO:0016582 protein binding; • protein binding involved in heterotypic cell-cell adhesion; • cell-cell adhesion mediator activity;
Cydrannau o'r gell	• integral component of membrane; • Cellbilen; • integral component of plasma membrane; • bilen; • specific granule membrane; • tertiary granule membrane; • extracellular exosome; • cell surface;
Prosesau biolegol	• integrin-mediated signaling pathway; • positive regulation of phagocytosis; • cell adhesion; • extracellular matrix organization; • positive regulation of inflammatory response; • positive regulation of T cell activation; • response to bacterium; • leukocyte migration; • positive regulation of cell population proliferation; • opsonization; • positive regulation of cell-cell adhesion; • neutrophil degranulation; • cell migration; • regulation of interferon-gamma production; • regulation of interleukin-10 production; • regulation of interleukin-12 production; • regulation of interleukin-6 production; • regulation of tumor necrosis factor production; • heterotypic cell-cell adhesion; • monocyte extravasation; • regulation of nitric oxide biosynthetic process; • positive regulation of stress fiber assembly; • cellular response to interferon-gamma; • cellular response to interleukin-1; • cellular response to interleukin-12; • cell-cell adhesion; • negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;
	Sources:Amigo / QuickGO
Orthologau
	961
	n/a
	ENSG00000196776
	n/a
	Q08722
	n/a
	NM_001025079; NM_001025080; NM_001777; NM_198793; NM_001382306
	n/a
	NP_001768; NP_942088; NP_001369235
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CD47 yw CD47 a elwir hefyd yn Leukocyte surface antigen CD47 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q13.12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD47.

IAP
OA3
MER6

Llyfryddiaeth

"Engineering macrophages to eat cancer: from "marker of self" CD47 and phagocytosis to differentiation. ". J Leukoc Biol. 2017. PMID 28522599.
"Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. ". Elife. 2017. PMID 28100392.
"Is CD47 an innate immune checkpoint for tumor evasion?". J Hematol Oncol. 2017. PMID 28077173.
"Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with CD47 blocking immunotherapy. ". Oncotarget. 2017. PMID 28076333.
"CD47 is a Potential Target for the Treatment of Laryngeal Squamous Cell Carcinoma.". Cell Physiol Biochem. 2016. PMID 27855370.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CD47 - Cronfa NCBI

[1]

[2]