Diphosphoinositol polyphosphate phosphohydrolase 1 is an enzyme that in humans is encoded by the NUDT3 gene.[5][6]

NUDT3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUDT3, DIPP, DIPP-1, DIPP1, nudix hydrolase 3
External IDsOMIM: 609228; MGI: 1928484; HomoloGene: 31400; GeneCards: NUDT3; OMA:NUDT3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006703

NM_001291046
NM_019837

RefSeq (protein)

NP_006694

NP_001277975
NP_062811

Location (UCSC)Chr 6: 34.28 – 34.39 MbChr 17: 27.8 – 27.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998).[supplied by OMIM][6]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000272325Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024213Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB (Jan 1999). "A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase". EMBO J. 17 (22): 6599–607. doi:10.1093/emboj/17.22.6599. PMC 1171006. PMID 9822604.
  6. ^ a b "Entrez Gene: NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3".

Further reading

edit