Gamma-aminobutyric acid (GABA) B receptor, 2 (GABAB2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans.[5]

GABBR2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGABBR2, GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099, gamma-aminobutyric acid type B receptor subunit 2, EIEE59, NDPLHS, DEE59
External IDsOMIM: 607340; MGI: 2386030; HomoloGene: 55902; GeneCards: GABBR2; OMA:GABBR2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005458

NM_001081141

RefSeq (protein)

NP_005449

NP_001074610

Location (UCSC)Chr 9: 98.29 – 98.71 MbChr 4: 46.66 – 46.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.[supplied by OMIM][5]

Interactions

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GABBR2 has been shown to interact with GABBR1.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136928Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039809Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2".
  6. ^ White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH (Dec 1998). "Heterodimerization is required for the formation of a functional GABA(B) receptor". Nature. 396 (6712): 679–82. Bibcode:1998Natur.396..679W. doi:10.1038/25354. PMID 9872316. S2CID 4406311.

Further reading

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  • "GABAB Receptors: GABAB2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  • Overview of all the structural information available in the PDB for UniProt: O75899 (Gamma-aminobutyric acid type B receptor subunit 2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.