HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.[5][6]

HLA-DOA
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesHLA-DOA, HLA-DNA, HLA-DZA, HLADZ, major histocompatibility complex, class II, DO alpha
External IDsOMIM: 142930; MGI: 95924; HomoloGene: 1601; GeneCards: HLA-DOA; OMA:HLA-DOA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002119
NM_015851

NM_008206

RefSeq (protein)

NP_002110

n/a

Location (UCSC)Chr 6: 33 – 33.01 MbChr 17: 34.31 – 34.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.[6]

References

edit
  1. ^ a b c ENSG00000230141, ENSG00000232962, ENSG00000235744, ENSG00000231558, ENSG00000206292, ENSG00000232957 GRCh38: Ensembl release 89: ENSG00000204252, ENSG00000230141, ENSG00000232962, ENSG00000235744, ENSG00000231558, ENSG00000206292, ENSG00000232957Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024334Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Young JA, Trowsdale J (Aug 1990). "The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript". Immunogenetics. 31 (5–6): 386–8. doi:10.1007/BF02115015. PMID 2370084. S2CID 31652916.
  6. ^ a b "Entrez Gene: HLA-DOA major histocompatibility complex, class II, DO alpha".

Further reading

edit