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Clomacran

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Clomacran
Clinical data
Trade namesDevryl, Olaxin,[1] Develar[2][3]
ATC code
Legal status
Legal status
Identifiers
  • 3-(2-chloro-9,10-dihydroacridin-9-yl)-N,N-dimethylpropan-1-amine
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H21ClN2
Molar mass300.83 g·mol−1
3D model (JSmol)
Density1.120 g/cm3 [1]
  • CN(C)CCCC1C2=CC=CC=C2NC3=C1C=C(C=C3)Cl
  • InChI=1S/C18H21ClN2/c1-21(2)11-5-7-14-15-6-3-4-8-17(15)20-18-10-9-13(19)12-16(14)18/h3-4,6,8-10,12,14,20H,5,7,11H2,1-2H3 checkY
  • Key:JFRLWWDJCFYFSU-UHFFFAOYSA-N checkY

Clomacran is an antipsychotic drug of the acridines class, developed in the 1970s[2] by the pharmaceutical company Smith, Kline & French under the brand names Devryl and Olaxin.[1]

It was withdrawn from the market in the UK, due to liver toxicity, in 1982.[5][6][7]

References

  1. ^ a b c "Clomacran | 5310-55-4". ChemicalBook. Retrieved 2023-08-25.
  2. ^ a b Elks, J.; Ganellin, C. R., eds. (1990). Dictionary of Drugs. Boston, MA: Springer US. p. 297. doi:10.1007/978-1-4757-2085-3. ISBN 978-1-4757-2087-7.
  3. ^ "Substâncias e remédios sob controle" [Substances and drugs under control] (PDF). Jornal do Brasil (in Brazilian Portuguese). 1986-11-05. p. 14. Archived (PDF) from the original on 2023-08-08. Retrieved 2023-08-08.
  4. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-03.
  5. ^ a b Dixit, Nandan; Patel, Chirag; Bhavsar, Mansi; Patel, Saumya; Rawal, Rakesh; Solanki, Hitesh (2022-05-02). "Quantitative Structure-activity Relationship (QSAR) study of Liver Toxic Drugs". International Association of Biologicals and Computational Digest: 63–71. doi:10.56588/iabcd.v1i1.17. eISSN 2583-3995.
  6. ^ "Clomacran". PubChem. Retrieved 2023-08-25.
  7. ^ Andrews, Elizabeth B.; Moore, Nicholas, eds. (2014). Mann's Pharmacovigilance (1 ed.). Wiley. doi:10.1002/9781118820186. ISBN 978-0-470-67104-7.
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