Integrin
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An integrin, or integrin receptor, is a receptor in the plasma membrane of biological cells. Integrins play an important role in:
- Integration of the cell into the surrounding tissue by
- cell-cell-interaction
- adhesive interaction
- Embryonal development
- Tumor development
- Apoptosis
- Connection between intracellular and extracellular scaffolding
Among the ligands of integrins are fibronectin and collagen, both part of the extracellular matrix. Ligand binding leads to clustering (cross-connection) of the multivalent components of the integrin to a functional protein complex. Integrins have no intrinsic kinase activity, but associate kinases (for example, focal adhesion kinase, FAK) on the cytoplasmic side of the membrane.