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| Players
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Coaches/Other
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Pitchers
- 39 Elian Almanzar
- 87 Rony Baez
- 52 Josh Burgmann
- 81 Yovanny Cabrera
- 96 Kelvin Feliz
- 91 Wilfri Figuerero
- 63 Angel Gonzalez
- 37 Drew Gray
- 32 Dominic Hambley
- 86 Angel Hernandez
- 58 Luke Little
- 55 Joel Machado
- 75 Gregori Montano
- -- Keon Moreno
- 49 Johzan Oquendo
- -- Benjamin Rodriguez
- 76 Andricson Salvador
- 30 Chase Watkins
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Catchers
- 97 Edgar Gamargo
- 3 Malcom Quintero
- 5 Ronnier Quintero
Infielders
- 70 Flemin Bautista
- 25 Juan Mora
- 12 Rafael Morel
- 56 B. J. Murray Jr.
- 1 Christian Olivo
- 9 Reginald Preciado
- -- Alejandro Rivero
- 41 Yeison Santana
- 8 James Triantos
Outfielders
- 24 Kevin Alcantara
- 43 Parker Chavers
- 80 Jose O. Lopez
- 29 Ismael Mena
- 64 Carlos Morfa
- 11 Ezequiel Pagan
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Manager
Coaches
- -- Jhonny Bethencourt
- -- Rachel Folden (hitting)
- -- Armando Gabino (pitching)
- -- Taylor Mark
- -- Doug Willey (pitching)
- -- Josh Zeid (rehab pitching)
 7-day injured list
* On Chicago Cubs 40-man roster
~ Development list
# Rehab assignment
∞ Reserve list
‡ Restricted list
§ Suspended list
† Temporarily inactive list
Roster updated April 1, 2022
Transactions
→ More rosters: MiLB • Arizona Complex League
→ Chicago Cubs minor league players
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