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Randy Schekman

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Randy Schekman
Schekman in 2012
Born
Randy Wayne Schekman

(1948-12-30) December 30, 1948 (age 75)
Saint Paul, Minnesota
Alma materUniversity of Edinburgh
Stanford University
UCLA
Known forEditor-in-chief of PNAS[3] and ELife[4]
AwardsLasker award (2002)
Massry Prize (2010)
Foreign Member of the Royal Society (ForMemRS) (2013)[1]
Nobel Prize in Physiology or Medicine (2013)
Scientific career
InstitutionsUniversity of California, Berkeley
Howard Hughes Medical Institute
Stanford University
UCLA
ThesisResolution and Reconstruction of a multienzyme DNA replication reaction (1975)
Doctoral advisorArthur Kornberg
Doctoral studentsDavid Julius[2]
Websitemcb.berkeley.edu/labs/schekman
royalsociety.org/people/randy-schekman

Randy Wayne Schekman (born December 30, 1948) is an American cell biologist at the University of California, Berkeley[5] and former editor-in-chief of Proceedings of the National Academy of Sciences.[3][6][7] In 2011 he was announced as the editor of eLife, a new high profile open access journal published by the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust launching in 2012.[8] He was elected to the National Academy of Sciences in 1992.[9]

Schekman was one of three researchers sharing the 2013 award of the Nobel Prize for Physiology or Medicine.

Early life

Schekman was born in Saint Paul, Minnesota to Alfred Schekman, an electrical engineer and inventor.[10] He received a BA in Molecular Sciences from the University of California, Los Angeles in 1971. He spent his third year at the University of Edinburgh in Scotland, as an exchange student.[11][12] He received a PhD in 1975 from Stanford University for research on DNA replication working with Arthur Kornberg.[13] He was promoted to Associate Professor in 1984 and Professor in 1994. In 2013, he married Stuart Linn, Ph.D., a biochemist.

Research

Since 1991, Schekman has been a Howard Hughes Medical Institute Investigator,[14] Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology at the University of California, Berkeley. The Schekman Lab at that university carries out research into molecular descriptions of the process of membrane assembly and vesicular traffic[15] in eukaryotic cells[16][17] including yeast.[18] Before that, he was a faculty member with the now disbanded Department of Biochemistry at the same university.

Awards

In 2002, Schekman received the Albert Lasker Award for Basic Medical Research[19] and Louisa Gross Horwitz Prize of Columbia University along with James Rothman for their discovery of cellular membrane trafficking, a process that cells use to organize their activities and communicate with their environment. He was awarded the Massry Prize from the Keck School of Medicine, University of Southern California in 2010. Schekman is also a member of the Selection Committee for Life Science and Medicine which chooses winners of the Shaw Prize.

In 2013 he was elected a Foreign Member of the Royal Society. His nomination read:

Using a brilliantly conceived genetic screen, Schekman isolated sec mutants that accumulate secretory pathway intermediates, he cloned the corresponding genes and he established biochemical reactions that faithfully reproduced specific secretory pathway events. These studies transformed the secretion field, previously descriptive and morphological, into a molecular and mechanistic one. The cell-free reactions that Schekman established led to his isolation of the Sec61 translocation complex, the (COPII) vesicle coat complex, and the first purified inter-organelle transport vesicles. The Sec proteins are strikingly conserved and the trafficking mechanisms that Schekman discovered are at the heart of neurotransmission, hormone secretion, cholesterol homeostasis and metabolic regulation.[1]

Schekman, Thomas C. Südhof, and James Rothman were awarded the 2013 Nobel Prize for Physiology or Medicine "for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells".[20]

References

  1. ^ a b "Professor Randy Schekman ForMemRS". Royalsociety.org. Retrieved October 7, 2013.
  2. ^ "Julius Lab - David Julius". Physio.ucsf.edu. Retrieved October 7, 2013.
  3. ^ a b Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 18287009, please use {{cite journal}} with |pmid=18287009 instead.
  4. ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.7554/eLife.00855, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.7554/eLife.00855 instead.
  5. ^ "Randy Schekman: Howard Hughes Investigator and Professor of Cell and Developmental Biology". Retrieved July 12, 2011.
  6. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 17051227, please use {{cite journal}} with |pmid=17051227 instead.
  7. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 17148596, please use {{cite journal}} with |pmid=17148596 instead.
  8. ^ "New journal editor named as Randy Schekman | Wellcome Trust". Retrieved July 12, 2011.
  9. ^ Randy Schekman publications indexed by Microsoft Academic
  10. ^ St. Paul native lands 2013 Nobel Prize in Medicine
  11. ^ "Randy Schekman, molecular biologist and UCLA alumnus, wins 2013 Nobel Prize". University of California, Los Angeles. Retrieved October 8, 2013.
  12. ^ "Profile of Randy Schekman: Reflections on his first year as PNAS Editor-in-Chief". National Academy of Sciences. Retrieved October 8, 2013.
  13. ^ Schekman, Randy Wayne (1975). Resolution and Reconstruction of a multienzyme DNA replication reaction (1975) (PhD thesis). Stanford University.
  14. ^ "HHMI Scientist Abstract: Randy W. Schekman, Ph.D." Retrieved July 12, 2011.
  15. ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1126/science.271.5255.1526, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1126/science.271.5255.1526 instead.
  16. ^ "Randy Schekman publications in Google Scholar". Retrieved July 12, 2011.
  17. ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1038/332800a0, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1038/332800a0 instead.
  18. ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1016/0092-8674(80)90128-2, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1016/0092-8674(80)90128-2 instead.
  19. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 12372293, please use {{cite journal}} with |pmid=12372293 instead.
  20. ^ "The Nobel Prize in Physiology or Medicine 2013". Nobel Foundation. Retrieved October 7, 2013.
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Academic offices
Preceded by ASCB Presidents
1999 		Succeeded by
Preceded by PNAS editor-in-chief
2006–2011 		Succeeded by
Preceded by
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 eLife editor-in-chief
2013–present 		Succeeded by
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