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ABLIM3

From Wikipedia, the free encyclopedia
ABLIM3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesABLIM3, HMFN1661, actin binding LIM protein family member 3
External IDsOMIM: 611305; MGI: 2442582; HomoloGene: 69175; GeneCards: ABLIM3; OMA:ABLIM3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001164491
NM_198649
NM_001360868

RefSeq (protein)

NP_001157963
NP_941051
NP_001347797

Location (UCSC)Chr 5: 149.14 – 149.26 MbChr 18: 61.93 – 62.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Actin-binding LIM protein 3 is a protein that in humans is encoded by the ABLIM3 gene.[5]

Function

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The LIM domain is a double zinc finger structure that promotes protein-protein interactions. LIM domain proteins, such as ABLIM3, play roles in embryonic development, cell lineage determination, and cancer.[6] An important paralog of this gene is LIMS1.

Clinical relevance

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Diseases associated with ABLIM3 include hepatoblastoma, and among its related super-pathways are axon guidance and DCC mediated attractive signaling.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173210Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032735Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ABLIM3 actin binding LIM protein family, member 3".
  6. ^ Krupp M, Weinmann A, Galle PR, Teufel A (Jan 2006). "Actin binding LIM protein 3 (abLIM3)". International Journal of Molecular Medicine. 17 (1): 129–33. doi:10.3892/ijmm.17.1.129. PMID 16328021.

Further reading

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