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Acrocylindropepsin

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Acrocylindropepsin
Identifiers
EC no.3.4.23.28
CAS no.37288-84-9
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Acrocylindropepsin (EC 3.4.23.28, Acrocylindrium proteinase, Acrocylindrium acid proteinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Preference for hydrophobic residues at P1 and P1'. Action on the B chain of insulin is generally similar to that of pepsin A, but it also cleaves Leu6-Cys(SO3H), Glu21-Arg and Asn3-Gln, although not Gln4-His

This enzyme is present in fungus Acrocylindrium sp.

References

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  1. ^ Uchino F, Kurono Y, Doi S (1967). "Purification and some properties of crystalline acid protease from Acrocylindrium sp". Agric. Biol. Chem. 31: 428–434. doi:10.1271/bbb1961.31.428.
  2. ^ Ichihara S, Uchino F (1975). "The specificity of acid proteinase from Acrocylindrium". Agric. Biol. Chem. 39: 423–428. doi:10.1271/bbb1961.39.423.
  3. ^ Takahashi K, Chang WJ (September 1976). "The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy) propane and pepstatin". Journal of Biochemistry. 80 (3): 497–506. PMID 10290.
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