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Blasticidin-S deaminase

From Wikipedia, the free encyclopedia
blasticidin-S deaminase
Identifiers
EC no.3.5.4.23
CAS no.54576-55-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a blasticidin-S deaminase (EC 3.5.4.23) is an enzyme that catalyzes the chemical reaction

blasticidin S + H2O deaminohydroxyblasticidin S + NH3

Thus, the two substrates of this enzyme are blasticidin S and H2O, whereas its two products are deaminohydroxyblasticidin S and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is blasticidin-S aminohydrolase.

Structural studies

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As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1WN5 and 1WN6.

References

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  • Yamaguchi I, Shibata H, Seto H, Misato T (January 1975). "Isolation and purification of blasticidin S deaminase from Aspergillus terreus". J. Antibiot. 28 (1). Tokyo: 7–14. doi:10.7164/antibiotics.28.7. PMID 236272.