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Bile-acid 7alpha-dehydroxylase

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Bile-acid 7alpha-dehydroxylase
Identifiers
EC no.1.17.99.5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

Bile-acid 7alpha-dehydroxylase (EC 1.17.99.5, cholate 7alpha-dehydroxylase, 7alpha-dehydroxylase, bile acid 7-dehydroxylase) was thought to be an enzyme with systematic name deoxycholate:NAD+ oxidoreductase.[1][2][3][4]

However, it was later shown that the dehydroxylation is carried out by seven different enzymes, catalyzing a total of 8 reactions. The enzymes are EC 6.2.1.7, EC 1.1.1.395, EC 1.3.1.115, EC 2.8.3.25, EC 4.2.1.106, EC 1.3.1.114, and EC 1.1.1.52.

References

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  1. ^ White BA, Cacciapuoti AF, Fricke RJ, Whitehead TR, Mosbach EH, Hylemon PB (August 1981). "Cofactor requirements for 7 alpha-dehydroxylation of cholic and chenodeoxycholic acid in cell extracts of the intestinal anaerobic bacterium, Eubacterium species V.P.I. 13708". Journal of Lipid Research. 22 (6): 891–8. PMID 7276750.
  2. ^ White BA, Paone DA, Cacciapuoti AF, Fricke RJ, Mosbach EH, Hylemon PB (January 1983). "Regulation of bile acid 7-dehydroxylase activity by NAD+ and NADH in cell extracts of Eubacterium species V.P.I. 12708". Journal of Lipid Research. 24 (1): 20–7. PMID 6833878.
  3. ^ Coleman JP, White WB, Hylemon PB (April 1987). "Molecular cloning of bile acid 7-dehydroxylase from Eubacterium sp. strain VPI 12708". Journal of Bacteriology. 169 (4): 1516–21. PMC 211977. PMID 3549693.
  4. ^ Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annual Review of Biochemistry. 72: 137–74. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.
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