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CELA2B

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CELA2B
Identifiers
AliasesCELA2B, ELA2B, chymotrypsin like elastase family member 2B, chymotrypsin like elastase 2B
External IDsOMIM: 609444; HomoloGene: 88835; GeneCards: CELA2B; OMA:CELA2B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015849

n/a

RefSeq (protein)

NP_056933

n/a

Location (UCSC)Chr 1: 15.47 – 15.49 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Chymotrypsin-like elastase family member 2B is and enzyme that in humans is encoded by the CELA2B gene.[3][4][5]

Function

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Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000215704Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Kawashima I, Tani T, Shimoda K, Takiguchi Y (April 1987). "Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas". DNA. 6 (2): 163–72. doi:10.1089/dna.1987.6.163. PMID 3646943.
  4. ^ Szepessy E, Sahin-Tóth M (2006). "Inactivity of Recombinant ELA2B Provides a New Example of Evolutionary Elastase Silencing in Humans". Pancreatology. 6 (1–2): 117–22. doi:10.1159/000090031. PMC 1447606. PMID 16327289.
  5. ^ a b "Entrez Gene: chymotrypsin-like elastase family".
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Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.