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CMP kinase

From Wikipedia, the free encyclopedia
CMPK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCMPK1, CK, CMK, CMPK, UMK, UMP-CMPK, UMPK, cytidine/uridine monophosphate kinase 1
External IDsOMIM: 191710; MGI: 1913838; HomoloGene: 32308; GeneCards: CMPK1; OMA:CMPK1 - orthologs
EC number2.7.4.6
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001136140
NM_016308
NM_001366135

NM_025647

RefSeq (protein)

NP_001129612
NP_057392
NP_001353064

NP_079923

Location (UCSC)Chr 1: 47.33 – 47.38 MbChr 4: 114.82 – 114.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

UMP-CMP kinase is an enzyme that in humans is encoded by the CMPK1 gene.[5][6]

Function

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Uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. These nucleoside diphosphates are required for cellular nucleic acid synthesis.[6][7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162368Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028719Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Van Rompay AR, Johansson M, Karlsson A (1999). "Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme". Molecular Pharmacology. 56 (3): 562–9. doi:10.1124/mol.56.3.562. PMID 10462544. S2CID 22945276.
  6. ^ a b EntrezGene 51727
  7. ^ Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC (2002). "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates". Cancer Research. 62 (6): 1624–31. PMID 11912132.
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Further reading

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