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Exodeoxyribonuclease III

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Exodeoxyribonuclease III
Identifiers
EC no.3.1.11.2
CAS no.9037-44-9
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Exodeoxyribonuclease III (EC 3.1.11.2, Escherichia coli exonuclease III, E. coli exonuclease III, endoribonuclease III) is an enzyme[1][2][3] that catalyses the following reaction

Exonucleolytic cleavage in the 3′- to 5′-direction to yield nucleoside 5′-phosphates

This enzyme has a preference for double-stranded DNA.

References

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  1. ^ Lindahl T, Gally JA, Edelman GM (September 1969). "Properties of deoxyribonuclease 3 from mammalian tissues". The Journal of Biological Chemistry. 244 (18): 5014–9. doi:10.1016/S0021-9258(18)94303-6. PMID 5824576.
  2. ^ Richardson CC, Kornberg A (January 1964). "A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. I. Purification of the enzyme and characterization of the phosphatase activity". The Journal of Biological Chemistry. 239: 242–50. doi:10.1016/S0021-9258(18)51774-9. PMID 14114850.
  3. ^ Richardson CC, Lehman IR, Kornberg A (January 1964). "A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. II. Characterization of the exonuclease activity". The Journal of Biological Chemistry. 239: 251–8. doi:10.1016/S0021-9258(18)51775-0. PMID 14114851.
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