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OPCML

From Wikipedia, the free encyclopedia
OPCML
Identifiers
AliasesOPCML, IGLON1, OBCAM, OPCM, opioid binding protein/cell adhesion molecule-like, opioid binding protein/cell adhesion molecule like
External IDsOMIM: 600632; MGI: 97397; HomoloGene: 55663; GeneCards: OPCML; OMA:OPCML - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_177906

RefSeq (protein)

n/a

Location (UCSC)Chr 11: 132.41 – 133.53 MbChr 9: 27.79 – 28.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Opioid-binding protein/cell adhesion molecule is a protein that in humans is encoded by the OPCML gene.[5][6]

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the cell membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183715Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062257Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y, et al. (Dec 1993). "A sequence-tagged site map of human chromosome 11". Genomics. 17 (3): 699–725. doi:10.1006/geno.1993.1392. PMID 8244387.
  6. ^ a b "Entrez Gene: OPCML opioid binding protein/cell adhesion molecule-like".

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: Q14982 (Opioid-binding protein/cell adhesion molecule) at the PDBe-KB.