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Phosphonate dehydrogenase

From Wikipedia, the free encyclopedia
phosphonate dehydrogenase
Identifiers
EC no.1.20.1.1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

In enzymology, a phosphonate dehydrogenase (EC 1.20.1.1) is an enzyme that catalyzes the chemical reaction

phosphonate + NAD+ + H2O phosphate + NADH + H+

The 3 substrates of this enzyme are phosphonate, NAD+, and H2O, whereas its 3 products are phosphate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on phosphorus or arsenic in donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is phosphonate:NAD+ oxidoreductase. Other names in common use include NAD:phosphite oxidoreductase, and phosphite dehydrogenase.

References

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  • Costas AM, White AK, Metcalf WW (2001). "Purification and characterization of a novel phosphorus-oxidizing enzyme from Pseudomonas stutzeri WM88". J. Biol. Chem. 276 (20): 17429–36. doi:10.1074/jbc.M011764200. PMID 11278981.
  • Vrtis JM, White AK, Metcalf WW, van der Donk WA (2001). "Phosphite dehydrogenase: an unusual phosphoryl transfer reaction". J. Am. Chem. Soc. 123 (11): 2672–3. doi:10.1021/ja004301k. PMID 11456941.