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Togavirin

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Togavirin
Identifiers
EC no.3.4.21.90
CAS no.342882-56-8
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Togavirin (EC 3.4.21.90, Sindbis virus protease, Sindbis virus core protein, NsP2 proteinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-Ser- bond

This enzyme is isolated from the Sindbis and Semliki forest togaviruses.

References

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  1. ^ Kräusslich HG, Wimmer E (1988). "Viral proteinases". Annual Review of Biochemistry. 57: 701–54. doi:10.1146/annurev.bi.57.070188.003413. PMID 3052288.
  2. ^ Strauss EG, De Groot RJ, Levinson R, Strauss JH (December 1992). "Identification of the active site residues in the nsP2 proteinase of Sindbis virus". Virology. 191 (2): 932–40. doi:10.1016/0042-6822(92)90268-t. PMC 7131396. PMID 1448929.
  3. ^ Tong L, Wengler G, Rossmann MG (March 1993). "Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures". Journal of Molecular Biology. 230 (1): 228–47. doi:10.1006/jmbi.1993.1139. PMID 8450538.
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