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ZHX1

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ZHX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesZHX1, zinc fingers and homeoboxes 1
External IDsOMIM: 604764; MGI: 109271; HomoloGene: 5225; GeneCards: ZHX1; OMA:ZHX1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001017926
NM_007222

NM_001042438
NM_009572

RefSeq (protein)

NP_001017926
NP_009153

NP_001035903
NP_033598

Location (UCSC)Chr 8: 123.25 – 123.28 MbChr 15: 57.91 – 57.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc fingers and homeoboxes protein 1 is a protein that in humans is encoded by the ZHX1 gene.[5][6]

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein.[6]

Interactions

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ZHX1 has been shown to interact with NFYA.[5][7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165156Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022361Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Yamada K, Printz RL, Osawa H, Granner DK (August 1999). "Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y". Biochemical and Biophysical Research Communications. 261 (3): 614–21. doi:10.1006/bbrc.1999.1087. PMID 10441475. S2CID 35415109.
  6. ^ a b "Entrez Gene: ZHX1 zinc fingers and homeoboxes 1".
  7. ^ Yamada K, Osawa H, Granner DK (October 1999). "Identification of proteins that interact with NF-YA". FEBS Letters. 460 (1): 41–5. doi:10.1016/S0014-5793(99)01311-3. PMID 10571058. S2CID 28576187.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: Q9UKY1 (Zinc fingers and homeoboxes protein 1) at the PDBe-KB.