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3-propylmalate synthase

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3-propylmalate synthase
Identifiers
EC no.2.3.3.12
CAS no.37290-62-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a 3-propylmalate synthase (EC 2.3.3.12) is an enzyme that catalyzes the chemical reaction

pentanoyl-CoA + H2O + glyoxylate 3-propylmalate + CoA

The 3 substrates of this enzyme are pentanoyl-CoA, H2O, and glyoxylate, whereas its two products are 3-propylmalate and CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is pentanoyl-CoA:glyoxylate C-pentanoyltransferase (thioester-hydrolysing, 1-carboxybutyl-forming). Other names in common use include 3-(n-propyl)-malate synthase, 3-propylmalate glyoxylate-lyase (CoA-pentanoylating), beta-n-propylmalate synthase, and n-propylmalate synthase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

References

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  • IMAI K, REEVES HC, AJL SJ (1963). "N-PROPYLMALATE SYNTHETASE". J. Biol. Chem. 238: 3193–8. PMID 14085361.