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1-异硫氰基-6-甲亚磺酰基己烷

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1-异硫氰基-6-甲亚磺酰基己烷
IUPAC名
1-Isothiocyanato-6-(methanesulfinyl)hexane
别名 6-MITC; 6-MSITC
异硫氰酸(6-甲亚磺酰基)己酯
(6-甲基亚磺酰基)己基硫氰酸酯
识别
CAS号 4430-35-7  checkY
PubChem 9815648
ChemSpider 7991398
SMILES
 
  • CS(=O)CCCCCN=C=S
ChEBI 138799
性质
化学式 C8H15NOS2
摩尔质量 205.34 g·mol−1
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

1-异硫氰基-6-甲亚磺酰基己烷异硫氰酸-6-甲亚磺酰基己酯是一种有机化合物,化学式为C8H15NOS2。它可由6-溴己腈甲硫醇钠二硫化碳间氯过氧苯甲酸为原料反应得到。[1]它存在于山葵中,是一种糖原合酶激酶3β英语GSK-3抑制剂。[2]有文献对其抗癌作用做了小鼠实验。[3]

参考文献

[编辑]
  1. ^ Ashida, Hitoshi; Hashimoto, Takashi. Cell cycle inhibitors containing Brassicaceae isothiocyanates, and topical preparations, cosmetics, and health foods containing them. 2006 JP 2006089394 A.
  2. ^ Jun Yoshida, Satomi Nomura, Naoyuki Nishizawa, Yoshiaki Ito, Ken-ichi Kimura. Glycogen Synthase Kinase-3β Inhibition of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi ( Wasabia japonica Matsum). Bioscience, Biotechnology, and Biochemistry. 2011-01-23, 75 (1): 136–139 [2022-02-26]. ISSN 0916-8451. doi:10.1271/bbb.100507 (英语). 
  3. ^ Yoko Fuke, Yoshiko Haga, Haruhiro Ono, Takahiro Nomura, Kazuo Ryoyama. Anti-carcinogenic activity of 6-methylsulfinylhexyl isothiocyanate-, an active anti-proliferative principal of wasabi (Eutrema wasabi Maxim.). Cytotechnology. 1997-11-01, 25 (1): 197 [2022-02-26]. ISSN 1573-0778. PMC 3466737可免费查阅. PMID 22358892. doi:10.1023/A:1007918508115 (英语).