The importance of being parasiticidal… an update on drug development for the treatment of alveolar echinococcosis (Q89869922)

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9 April 2020

title

The importance of being parasiticidal… an update on drug development for the treatment of alveolar echinococcosis (English)

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9 April 2020

main subject

alveolar echinococcosis

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Britta Lundström-Stadelmann

inferred from title

author

1

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9 April 2020

Dominic Ritler

3

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9 April 2020

author name string

Reto Rufener

2

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9 April 2020

Raphael Zurbriggen

4

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9 April 2020

Andrew Hemphill

5

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9 April 2020

publication date

14 March 2019

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9 April 2020

volume

15

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9 April 2020

page(s)

e00040

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Effects of multiple doses of isoprinosine on Echinococcus multilocularis metacestodes

9 April 2020

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Long-term in vitro cultivation of Echinococcus multilocularis metacestodes under axenic conditions

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Hepatic alveolar echinococcosis in cynomolgus monkeys (Macaca fascicularis).

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Mode of action of benzimidazoles

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Mitochondrial ribosome as the target for the macrolide antibiotic clarithromycin in the helminth Echinococcus multilocularis

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12 December 2020

Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections

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12 December 2020

In vitro activities of itraconazole, methiazole, and nitazoxanide versus Echinococcus multilocularis larvae

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12 December 2020

In vitro metacestodicidal activities of genistein and other isoflavones against Echinococcus multilocularis and Echinococcus granulosus

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12 December 2020

F-18-fluorodeoxyglucose (FDG) positron-emission tomography of Echinococcus multilocularis liver lesions: prospective evaluation of its value for diagnosis and follow-up during benzimidazole therapy.

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12 December 2020

Anaerobic NADH-fumarate reductase system is predominant in the respiratory chain of Echinococcus multilocularis, providing a novel target for the chemotherapy of alveolar echinococcosis

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12 December 2020

Transient transfection of Echinococcus multilocularis primary cells and complete in vitro regeneration of metacestode vesicles

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12 December 2020

In vitro and in vivo effects of 2-methoxyestradiol, either alone or combined with albendazole, against Echinococcus metacestodes

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Alveolar echinococcosis: from a deadly disease to a well-controlled infection. Relative survival and economic analysis in Switzerland over the last 35 years.

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In vitro and in vivo treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives

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12 December 2020

Thiazolides inhibit growth and induce glutathione-S-transferase Pi (GSTP1)-dependent cell death in human colon cancer cells

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12 December 2020

Characterization and inhibition of a p38-like mitogen-activated protein kinase (MAPK) from Echinococcus multilocularis: antiparasitic activities of p38 MAPK inhibitors

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12 December 2020

Mefloquine--an aminoalcohol with promising antischistosomal properties in mice

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Thioureides of 2-(phenoxymethyl)benzoic acid 4-R substituted: a novel class of anti-parasitic compounds.

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12 December 2020

Limitations of amphotericin B and nitazoxanide in the treatment of alveolar echinococcosis

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Dose-response relationships and tegumental surface alterations in Opisthorchis viverrini following treatment with mefloquine in vivo and in vitro

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12 December 2020

Echinococcus metacestodes as laboratory models for the screening of drugs against cestodes and trematodes.

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Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni

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Molecular characterisation of MEK1/2- and MKK3/6-like mitogen-activated protein kinase kinases (MAPKK) from the fox tapeworm Echinococcus multilocularis

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12 December 2020

Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans

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12 December 2020

Echinococcus multilocularis as an experimental model in stem cell research and molecular host-parasite interaction.

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12 December 2020

Application of an in vitro drug screening assay based on the release of phosphoglucose isomerase to determine the structure-activity relationship of thiazolides against Echinococcus multilocularis metacestodes.

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12 December 2020

The role of evolutionarily conserved signalling systems in Echinococcus multilocularis development and host-parasite interaction

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12 December 2020

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In vitro and in vivo efficacies of mefloquine-based treatment against alveolar echinococcosis.

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In vitro efficacy of dicationic compounds and mefloquine enantiomers against Echinococcus multilocularis metacestodes

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A new promising application for highly cytotoxic metal compounds: η6-areneruthenium(II) phosphite complexes for the treatment of alveolar echinococcosis

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Echinococcus granulosus tegumental enzymes as in vitro markers of pharmacological damage: a biochemical and molecular approach.

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Voluntary ingestion of antiparasitic drugs emulsified in honey represents an alternative to gavage in mice

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In vitro efficacy of the anticancer drug imatinib on Echinococcus multilocularis larvae

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In vitro and in vivo activities of dicationic diguanidino compounds against Echinococcus multilocularis metacestodes

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Subcutaneous infection model facilitates treatment assessment of secondary Alveolar echinococcosis in mice

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Amino ozonides exhibit in vitro activity against Echinococcus multilocularis metacestodes

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Targeting Echinococcus multilocularis stem cells by inhibition of the Polo-like kinase EmPlk1

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Efficacy of albendazole in combination with thymol against Echinococcus multilocularis protoscoleces and metacestodes.

1 reference

12 December 2020

Profound activity of the anti-cancer drug bortezomib against Echinococcus multilocularis metacestodes identifies the proteasome as a novel drug target for cestodes

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12 December 2020

Repurposing drugs for the treatment and control of helminth infections

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12 December 2020

Serum albumin and α-1 acid glycoprotein impede the killing of Schistosoma mansoni by the tyrosine kinase inhibitor Imatinib

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12 December 2020

Treatment of echinococcosis: albendazole and mebendazole--what else?

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12 December 2020

On the importance of targeting parasite stem cells in anti-echinococcosis drug development.

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12 December 2020

Deletion of Fibrinogen-like Protein 2 (FGL-2), a Novel CD4+ CD25+ Treg Effector Molecule, Leads to Improved Control of Echinococcus multilocularis Infection in Mice

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12 December 2020

Prevention and Immunotherapy of Secondary Murine Alveolar Echinococcosis Employing Recombinant EmP29 Antigen

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12 December 2020

Threat of alveolar echinococcosis to public health--a challenge for Europe

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12 December 2020

In vivo activity of albendazole in combination with thymol against Echinococcus multilocularis

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12 December 2020

Description of vertebral and liver alveolar echinococcosis cases in Cynomolgus monkeys (Macaca fascicularis).

1 reference

12 December 2020

Recent advances in Echinococcus genomics and stem cell research

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12 December 2020

Efficacy of Albendazole-Chitosan Microsphere-based Treatment for Alveolar Echinococcosis in Mice

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12 December 2020

Oral treatments of Echinococcus multilocularis-infected mice with the antimalarial drug mefloquine that potentially interacts with parasite ferritin and cystatin.

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12 December 2020

Niclosamide inhibits epithelial-mesenchymal transition and tumor growth in lapatinib-resistant human epidermal growth factor receptor 2-positive breast cancer

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Cystic Echinococcosis

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Ruthenium(II) complexes of 1,3-thiazolidine-2-thione: Cytotoxicity against tumor cells and anti-Trypanosoma cruzi activity enhanced upon combination with benznidazole

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Comparative Evaluation of Liposomal Albendazole and Tablet-Albendazole Against Hepatic Cystic Echinococcosis: A Non-Randomized Clinical Trial

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Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis

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Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents

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Efficacy of osthole for Echinococcus granulosus in vitro and Echinococcus multilocularis in vivo

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Public Health Follow-up of Suspected Exposure to Echinococcus multilocularis in Southwestern Ontario

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Echinococcus-Host Interactions at Cellular and Molecular Levels

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Global Distribution of Alveolar and Cystic Echinococcosis.

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To see or not to see: non-invasive imaging for improved readout of drug treatment trials in the murine model of secondary alveolar echinococcosis.

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Development of a movement-based in vitro screening assay for the identification of new anti-cestodal compounds.

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Albendazole increases the inflammatory response and the amount of Em2-positive small particles of Echinococcus multilocularis (spems) in human hepatic alveolar echinococcosis lesions

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Depletion of FoxP3(+) Tregs improves control of larval Echinococcus multilocularis infection by promoting co-stimulation and Th1/17 immunity

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Characterization of the Activities of Dinuclear Thiolato-Bridged Arene Ruthenium Complexes against Toxoplasma gondii.

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The Microbiology of Ruthenium Complexes

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Dogs as victims of their own worms: Serodiagnosis of canine alveolar echinococcosis.

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Mefloquine for preventing malaria during travel to endemic areas

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Albendazole nanocrystals in experimental alveolar echinococcosis: Enhanced chemoprophylactic and clinical efficacy in infected mice.

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12 December 2020

The effects of taxanes, vorinostat and doxorubicin on growth and proliferation of Echinococcus multilocularis metacestodes assessed with magnetic resonance imaging and simultaneous positron emission tomography.

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Evaluation of kinase-inhibitors nilotinib and everolimus against alveolar echinococcosis in vitro and in a mouse model.

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Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets.

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12 December 2020

Intense Focus of Alveolar Echinococcosis, South Kyrgyzstan.

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12 December 2020

Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis

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12 December 2020

Foxp3 T Regulatory Cells as a Potential Target for Immunotherapy against Primary Infection with Echinococcus multilocularis Eggs

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12 December 2020

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12 December 2020

Immunotherapy of alveolar echinococcosis via PD-1/PD-L1 immune checkpoint blockade in mice

1 reference

12 December 2020

Repurposing of an old drug: In vitro and in vivo efficacies of buparvaquone against Echinococcus multilocularis

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12 December 2020

Psychological burden and resilience factors in patients with Alveolar Echinococcosis - A cross-sectional study

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Comprehensive diagnosis and treatment of alveolar echinococcosis: A single-center, long-term observational study of 312 patients in Germany

1 reference

12 December 2020

10.1016/J.FAWPAR.2019.E00040

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32095613%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32095613%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

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