(Q21112920)

English

Cullin 4A

mammalian protein found in Homo sapiens

CUL-4A
CUL4A
cullin-4A
CUL4A protein, human

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Winged helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13619

Cullin homology domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13619

Winged helix-like DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13619

Cullin repeat-like-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13619

Cullin, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cullin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cullin protein, neddylation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cullin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

ubiquitin protein ligase activity

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

protein binding

determination method

15 references

1 January 2018

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

TIP120A associates with cullins and modulates ubiquitin ligase activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

Cul4-RING E3 ubiquitin ligase complex

determination method

cullin-RING ubiquitin ligase complex

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619

determination method

Cul4A-RING E3 ubiquitin ligase complex

determination method

6 references

24 April 2018

DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619

determination method

24 April 2018

CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619

determination method

24 April 2018

Identification of a primary target of thalidomide teratogenicity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619

determination method

24 April 2018

Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619

determination method

24 April 2018

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619

determination method

24 April 2018

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619

determination method

Cul4A-RING E3 ubiquitin ligase complex

determination method

7 references

1 January 2018

Identification of a primary target of thalidomide teratogenicity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

Cul4-RING E3 ubiquitin ligase complex

determination method

3 references

1 January 2018

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

SCF ubiquitin ligase complex

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

biological process

negative regulation of granulocyte differentiation

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

nucleotide-excision repair, DNA damage recognition

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

negative regulation of cell population proliferation

determination method

1 reference

1 January 2018

cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

positive regulation of G1/S transition of mitotic cell cycle

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

intrinsic apoptotic signaling pathway

determination method

1 reference

1 January 2018

cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

regulation of protein metabolic process

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

somatic stem cell population maintenance

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

nucleotide-excision repair, DNA incision

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

transcription-coupled nucleotide-excision repair

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

positive regulation of cell population proliferation

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

regulation of DNA damage checkpoint

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

global genome nucleotide-excision repair

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

in utero embryonic development

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

regulation of nucleotide-excision repair

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

nucleotide-excision repair, DNA incision, 5'-to lesion

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

nucleotide-excision repair, preincision complex stabilization

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

nucleotide-excision repair, preincision complex assembly

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

post-translational protein modification

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

G1/S transition of mitotic cell cycle

determination method

1 reference

1 January 2018

cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

ubiquitin-dependent protein catabolic process

determination method

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

3 references

1 January 2018

Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

nucleotide-excision repair, DNA duplex unwinding

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

nucleotide-excision repair, DNA incision, 3'-to lesion

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

protein ubiquitination

determination method

3 references

1 January 2018

Selective degradation of splicing factor CAPERα by anticancer sulfonamides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

1 January 2018

CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619

determination method

physically interacts with

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL468

Identifiers

MeSH descriptor ID

subject named as

CUL4A protein, human

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000480367

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000480367

ENSP00000364589

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000364589

ENSP00000389118

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000389118

ENSP00000481782

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000481782

ENSP00000364590

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000364590

ENSP00000322132

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000322132

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21112920&oldid=2022951537"