Taurohenodezoksiholat 6α-hidroksilaza

(Preusmjereno sa stranice CYP3A4)

Taurohenodezoksiholat 6α-hidroksilaza (EC 1.14.13.97, CYP3A4, CYP4A21, taurohenodezoksiholat 6alfa-monooksigenaza) je enzim sa sistematskim imenom taurohenodezoksiholat,NADPH:kiseonik oksidoreduktaza (6alfa-hidroksilacija).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Taurohenodezoksiholat 6α-hidroksilaza
Identifikatori
EC broj 1.14.13.97
CAS broj 105669-85-0
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
(1) taurohenodezoksiholat + NADPH + H+ + O2 taurohioholat + NADP+ + H2O
(2) lithoholat + NADPH + H+ + O2 hiodezoksiholat + NADP+ + H2O

Ovaj enzim je hem-tiolatni protein (P-450). Za maksimalnu aktivnost je neophodan citohrom b5.

Reference

uredi
  1. Araya, Z. and Wikvall, K. (1999). „6α-Hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes”. Biochim. Biophys. Acta 1438: 47-54. PMID 10216279. 
  2. Araya, Z., Hellman, U. and Hansson, R. (1995). „Characterisation of taurochenodeoxycholic acid 6α-hydroxylase from pig liver microsomes”. Eur. J. Biochem. 231: 855-861. PMID 7649186. 
  3. Kramer, W., Sauber, K., Baringhaus, K.H., Kurz, M., Stengelin, S., Lange, G., Corsiero, D., Girbig, F., Konig, W. and Weyland, C. (2001). „Identification of the bile acid-binding site of the ileal lipid-binding protein by photoaffinity labeling, matrix-assisted laser desorption ionization-mass spectrometry, and NMR structure”. J. Biol. Chem. 276: 7291-7301. PMID 11069906. 
  4. Lundell, K., Hansson, R. and Wikvall, K. (2001). „Cloning and expression of a pig liver taurochenodeoxycholic acid 6α-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily”. J. Biol. Chem. 276: 9606-9612. PMID 11113117. 
  5. Lundell, K. and Wikvall, K. (2003). „Gene structure of pig sterol 12α-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6α-hydroxylase (CYP4A21)”. Biochim. Biophys. Acta 1634: 86-96. PMID 14643796. 
  6. Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137-174. PMID 12543708. 

Literatura

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