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Melanin-koncentrirajući hormonski receptor 1 — разлика између измена

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{{PBB_Summary
{{PBB_Summary
| section_title =
| section_title =
| summary_text = Protein kodiran ovim genom je član [[GPCR|G protein-spregnuti receptor]] familije 1. On je integralni protein membrane plazme koji vezuje [[Melanin koncentrirajući hormon|melanin-koncentrirajući hormon]]. Ovaj receptor može da inhibira [[Ciklični adenozin monofosfat|-{cAMP}-]] akumulaciju, i da stimuliše intracelularni kalcijum fluks. Smatra se da on učestvuje u neuronalnoj regulaciju konzumacije hrane. Mada je strukturno sličan sa [[somatostatin receptor]]ima, ovaj protein ne vezuje [[somatostatin]].<ref name="entrez">{{cite web | title = Entrez Gene: MCHR1 melanin-concentrating hormone receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2847| accessdate = }}</ref>
| summary_text = Protein kodiran ovim genom je član [[G protein spregnuti receptori|G protein-spregnuti receptor]] familije 1. On je integralni protein membrane plazme koji vezuje [[Melanin koncentrirajući hormon|melanin-koncentrirajući hormon]]. Ovaj receptor može da inhibira [[Ciklični adenozin monofosfat|-{cAMP}-]] akumulaciju, i da stimuliše intracelularni kalcijum fluks. Smatra se da on učestvuje u neuronalnoj regulaciju konzumacije hrane. Mada je strukturno sličan sa [[somatostatin receptor]]ima, ovaj protein ne vezuje [[somatostatin]].<ref name="entrez" />
}}
}}


==Funkcija==
==Funkcija==


-{MCH}-<sub>1</sub> ima brojne funkcije, u koje se ubrajaju regulacija apetita,<ref name="pmid17655875">{{cite journal |author=Luthin DR |title=Anti-obesity effects of small molecule melanin-concentrating hormone receptor 1 (MCHR1) antagonists |journal=Life Sciences |volume=81 |issue=6 |pages=423–40 |year=2007 |month=July |pmid=17655875 |doi=10.1016/j.lfs.2007.05.029 |url=}}</ref><ref name="pmid18393860">{{cite journal |author=Rivera G, Bocanegra-García V, Galiano S, Cirauqui N, Ceras J, Pérez S, Aldana I, Monge A |title=Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity |journal=Current Medicinal Chemistry |volume=15 |issue=10 |pages=1025–43 |year=2008 |pmid=18393860 |doi= 10.2174/092986708784049621|url=}}</ref> kao i posredovanje stresa, strepnje i depresije.<ref name="pmid12885269">{{cite journal |author=Hervieu G |title=Melanin-concentrating hormone functions in the nervous system: food intake and stress |journal=Expert Opinion on Therapeutic Targets |volume=7 |issue=4 |pages=495–511 |year=2003 |month=August |pmid=12885269 |doi=10.1517/14728222.7.4.495 |url=}}</ref><ref name="pmid16999451">{{cite journal |author=Shimazaki T, Yoshimizu T, Chaki S |title=Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders |journal=CNS Drugs |volume=20 |issue=10 |pages=801–11 |year=2006 |pmid=16999451 |doi= |url=}}</ref><ref name="pmid16548771">{{cite journal |author=Hervieu GJ |title=Further insights into the neurobiology of melanin-concentrating hormone in energy and mood balances |journal=Expert Opinion on Therapeutic Targets |volume=10 |issue=2 |pages=211–29 |year=2006 |month=April |pmid=16548771 |doi=10.1517/14728222.10.2.211 |url=}}</ref><ref name="pmid16205780">{{cite journal |author=Smith DG, Davis RJ, Rorick-Kehn L, Morin M, Witkin JM, McKinzie DL, Nomikos GG, Gehlert DR |title=Melanin-concentrating hormone-1 receptor modulates neuroendocrine, behavioral, and corticolimbic neurochemical stress responses in mice |journal=Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology |volume=31 |issue=6 |pages=1135–45 |year=2006 |month=June |pmid=16205780 |doi=10.1038/sj.npp.1300913 |url=}}</ref><ref name="pmid16934771">{{cite journal |author=Roy M, David N, Cueva M, Giorgetti M |title=A study of the involvement of melanin-concentrating hormone receptor 1 (MCHR1) in murine models of depression |journal=Biological Psychiatry |volume=61 |issue=2 |pages=174–80 |year=2007 |month=January |pmid=16934771 |doi=10.1016/j.biopsych.2006.03.076 |url=}}</ref><ref name="pmid18227983">{{cite journal |author=Saito Y, Nagasaki H |title=The melanin-concentrating hormone system and its physiological functions |journal=Results and Problems in Cell Differentiation |volume=46 |issue= |pages=159–79 |year=2008 |pmid=18227983 |doi=10.1007/400_2007_052 |url=}}</ref>
-{MCH}-<sub>1</sub> ima brojne funkcije, u koje se ubrajaju regulacija apetita,<ref name="pmid17655875">{{cite journal |author=Luthin DR |title=Anti-obesity effects of small molecule melanin-concentrating hormone receptor 1 (MCHR1) antagonists |journal=Life Sciences |volume=81 |issue=6 |pages=423–40 |year=2007 |pmid=17655875 |doi=10.1016/j.lfs.2007.05.029 |url=}}</ref><ref name="pmid18393860">{{cite journal |vauthors=Rivera G, Bocanegra-García V, Galiano S, Cirauqui N, Ceras J, Pérez S, Aldana I, Monge A |title=Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity |journal=Current Medicinal Chemistry |volume=15 |issue=10 |pages=1025–43 |year=2008 |pmid=18393860 |doi= 10.2174/092986708784049621|url=}}</ref> kao i posredovanje stresa, strepnje i depresije.<ref name="pmid12885269">{{cite journal |author=Hervieu G |title=Melanin-concentrating hormone functions in the nervous system: food intake and stress |journal=Expert Opinion on Therapeutic Targets |volume=7 |issue=4 |pages=495–511 |year=2003 |pmid=12885269 |doi=10.1517/14728222.7.4.495 |url=}}</ref><ref name="pmid16999451">{{cite journal |vauthors=Shimazaki T, Yoshimizu T, Chaki S |title=Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders |journal=CNS Drugs |volume=20 |issue=10 |pages=801–11 |year=2006 |pmid=16999451 |doi= |url=}}</ref><ref name="pmid16548771">{{cite journal |author=Hervieu GJ |title=Further insights into the neurobiology of melanin-concentrating hormone in energy and mood balances |journal=Expert Opinion on Therapeutic Targets |volume=10 |issue=2 |pages=211–29 |year=2006 |pmid=16548771 |doi=10.1517/14728222.10.2.211 |url=}}</ref><ref name="pmid16205780">{{cite journal |vauthors=Smith DG, Davis RJ, Rorick-Kehn L, Morin M, Witkin JM, McKinzie DL, Nomikos GG, Gehlert DR |title=Melanin-concentrating hormone-1 receptor modulates neuroendocrine, behavioral, and corticolimbic neurochemical stress responses in mice |journal=Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology |volume=31 |issue=6 |pages=1135–45 |year=2006 |pmid=16205780 |doi=10.1038/sj.npp.1300913 |url=}}</ref><ref name="pmid16934771">{{cite journal |vauthors=Roy M, David N, Cueva M, Giorgetti M |title=A study of the involvement of melanin-concentrating hormone receptor 1 (MCHR1) in murine models of depression |journal=Biological Psychiatry |volume=61 |issue=2 |pages=174–80 |year=2007 |pmid=16934771 |doi=10.1016/j.biopsych.2006.03.076 |url=}}</ref><ref name="pmid18227983">{{cite journal |vauthors=Saito Y, Nagasaki H |title=The melanin-concentrating hormone system and its physiological functions |journal=Results and Problems in Cell Differentiation |volume=46 |issue= |pages=159–79 |year=2008 |pmid=18227983 |doi=10.1007/400_2007_052 |url=}}</ref>


==Selektivni Ligandi==
==Selektivni Ligandi==
===Agonisti===
===Agonisti===
* [[Melanin koncentrirajući hormone]] (-{MCH}-)
* -{S}--36057 - modifikovani -{MCH}- 6-13 fragment zamenjen sa 3-jodotirozinom na -{N}--terminusu putem dioksioktanoil linkera. Koristi se kao <sup>125</sup>-{I}- [[izotopski obeležen|radioligand]] za -{MCH}-<sub>1</sub> mapiranje -{''in vivo''}-.<ref name="pmid11375253">{{cite journal |vauthors=Audinot V, Lahaye C, Suply T, Beauverger P, Rodriguez M, Galizzi JP, Fauchère JL, Boutin JA |title=[125I]-S36057: a new and highly potent radioligand for the melanin-concentrating hormone receptor |journal=British Journal of Pharmacology |volume=133 |issue=3 |pages=371–8 |year=2001 |pmid=11375253 |pmc=1572795 |doi=10.1038/sj.bjp.0704085 |url=https://archive.org/details/sim_british-journal-of-pharmacology_2001-06_133_3/page/371}}</ref><ref name="pmid19540226">{{cite journal |vauthors=Able SL, Ivarsson M, Fish RL, Clarke TL, McCourt C, Duckworth JM, Napier C, Katugampola SD |title=Localisation of melanin-concentrating hormone receptor 1 in rat brain and evidence that sleep parameters are not altered despite high central receptor occupancy |journal=European Journal of Pharmacology |volume= 616|issue= 1-3|pages= 101–6|year=2009 |pmid=19540226 |doi=10.1016/j.ejphar.2009.06.009 |url=}}</ref>


===Antagonisti===


* -{ATC-0065}-
* -{[[ATC-0175]]}-<ref name="pmid16614734">{{cite journal |vauthors=Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y |title=ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety |journal=CNS Drug Reviews |volume=11 |issue=4 |pages=341–52 |year=2005 |pmid=16614734 |doi= |url=}}</ref>
* -{[[GW-803,430]]}-<ref name="pmid19182070">{{cite journal |vauthors=Gehlert DR, Rasmussen K, Shaw J, Li X, Ardayfio P, Craft L, Coskun T, Zhang HY, Chen Y, Witkin JM |title=Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=329 |issue=2 |pages=429–38 |year=2009 |pmid=19182070 |doi=10.1124/jpet.108.143362 |url=https://archive.org/details/sim_journal-of-pharmacology-and-experimental-therapeutics_2009-05_329_2/page/429}}</ref>
* -{[[NGD-4715]]}-
* -{[[SNAP-7941]]}-<ref name="pmid12783607">{{cite journal |author=Doggrell SA |title=Does the melanin-concentrating hormone antagonist SNAP-7941 deserve 3As? |journal=Expert Opinion on Investigational Drugs |volume=12 |issue=6 |pages=1035–8 |year=2003 |pmid=12783607 |doi=10.1517/13543784.12.6.1035 |url=}}</ref>
* -{[[SNAP-94847]]}-<ref name="pmid17237257">{{cite journal |vauthors=David DJ, Klemenhagen KC, Holick KA, Saxe MD, Mendez I, Santarelli L, Craig DA, Zhong H, Swanson CJ, Hegde LG, Ping XI, Dong D, Marzabadi MR, Gerald CP, Hen R |title=Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=321 |issue=1 |pages=237–48 |year=2007 |pmid=17237257 |doi=10.1124/jpet.106.109678 |url=}}</ref>
* -{T-226,296}-<ref name="pmid11909603">{{cite journal |vauthors=Takekawa S, Asami A, Ishihara Y, Terauchi J, Kato K, Shimomura Y, Mori M, Murakoshi H, Kato K, Suzuki N, Nishimura O, Fujino M |title=T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist |journal=European Journal of Pharmacology |volume=438 |issue=3 |pages=129–35 |year=2002 |pmid=11909603 |doi= 10.1016/S0014-2999(02)01314-6|url=}}</ref>


===Antagonisti===
==Vidi još==

*[[Melanin-koncentrirajući hormone receptor]]


==Literatura==
==Literatura==
{{reflist|2}}
{{reflist|2}}

==Dodatna literatura==
{{Литература | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal |author1=Kolakowski LF |author2=Jung BP |author3=Nguyen T |author4=''et al.'' |title=Characterization of a human gene related to genes encoding somatostatin receptors. |journal=FEBS Lett. |volume=398 |issue= 2-3 |pages= 253–8 |year= 1997 |pmid= 8977118 |doi=10.1016/S0014-5793(96)01160-X }}
*{{cite journal |author1=Chambers J |author2=Ames RS |author3=Bergsma D |author4=''et al.'' |title=Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. |journal=Nature |volume=400 |issue= 6741 |pages= 261–5 |year= 1999 |pmid= 10421367 |doi= 10.1038/22313 }}
*{{cite journal |author1=Saito Y |author2=Nothacker HP |author3=Wang Z |author4=''et al.'' |title=Molecular characterization of the melanin-concentrating-hormone receptor. |journal=Nature |volume=400 |issue= 6741 |pages= 265–9 |year= 1999 |pmid= 10421368 |doi= 10.1038/22321 }}
*{{cite journal |author1=Shimomura Y |author2=Mori M |author3=Sugo T |author4=''et al.'' |title=Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=261 |issue= 3 |pages= 622–6 |year= 1999 |pmid= 10441476 |doi= 10.1006/bbrc.1999.1104 }}
*{{cite journal |author1=Dunham I |author2=Shimizu N |author3=Roe BA |author4=''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal |author1=Macdonald D |author2=Murgolo N |author3=Zhang R |author4=''et al.'' |title=Molecular characterization of the melanin-concentrating hormone/receptor complex: identification of critical residues involved in binding and activation. |journal=Mol. Pharmacol. |volume=58 |issue= 1 |pages= 217–25 |year= 2000 |pmid= 10860944 |doi= }}
*{{cite journal |author1=An S |author2=Cutler G |author3=Zhao JJ |author4=''et al.'' |title=Identification and characterization of a melanin-concentrating hormone receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7576–81 |year= 2001 |pmid= 11416225 |doi= 10.1073/pnas.131200698 | pmc=34710 }}
*{{cite journal |author1=Bednarek MA |author2=Feighner SD |author3=Hreniuk DL |author4=''et al.'' |title=Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2. |journal=Biochemistry |volume=40 |issue= 31 |pages= 9379–86 |year= 2001 |pmid= 11478907 |doi=10.1021/bi010867p }}
*{{cite journal |author1=Bednarek MA |author2=Tan C |author3=Hreniuk DL |author4=''et al.'' |title=Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13821–6 |year= 2002 |pmid= 11839762 |doi= 10.1074/jbc.M200563200 }}
*{{cite journal |author1=Audinot V |author2=Lahaye C |author3=Suply T |author4=''et al.'' |title=SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 4 |pages= 841–8 |year= 2002 |pmid= 12127971 |doi=10.1016/S0006-291X(02)00763-5 }}
*{{cite journal |author1=Hoogduijn MJ |author2=Ancans J |author3=Suzuki I |author4=''et al.'' |title=Melanin-concentrating hormone and its receptor are expressed and functional in human skin. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 3 |pages= 698–701 |year= 2002 |pmid= 12176038 |doi=10.1016/S0006-291X(02)00932-4 }}
*{{cite journal |vauthors=Bächner D, Kreienkamp HJ, Richter D |title=MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein. |journal=FEBS Lett. |volume=526 |issue= 1-3 |pages= 124–8 |year= 2002 |pmid= 12208518 |doi=10.1016/S0014-5793(02)03115-0 }}
*{{cite journal |author1=Verlaet M |author2=Adamantidis A |author3=Coumans B |author4=''et al.'' |title=Human immune cells express ppMCH mRNA and functional MCHR1 receptor. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 205–10 |year= 2002 |pmid= 12220661 |doi=10.1016/S0014-5793(02)03232-5 }}
*{{cite journal |author1=Strausberg RL |author2=Feingold EA |author3=Grouse LH |author4=''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal |author1=Logan DW |author2=Bryson-Richardson RJ |author3=Pagán KE |author4=''et al.'' |title=The structure and evolution of the melanocortin and MCH receptors in fish and mammals. |journal=Genomics |volume=81 |issue= 2 |pages= 184–91 |year= 2003 |pmid= 12620396 |doi=10.1016/S0888-7543(02)00037-X }}
*{{cite journal |vauthors=Pissios P, Trombly DJ, Tzameli I, Maratos-Flier E |title=Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways. |journal=Endocrinology |volume=144 |issue= 8 |pages= 3514–23 |year= 2003 |pmid= 12865333 |doi=10.1210/en.2002-0004 }}
*{{cite journal |author1=Gottumukkala RV |author2=Waterman EA |author3=Herd LM |author4=''et al.'' |title=Autoantibodies in vitiligo patients recognize multiple domains of the melanin-concentrating hormone receptor. |url=https://archive.org/details/sim_journal-of-investigative-dermatology_2003-10_121_4/page/765 |journal=J. Invest. Dermatol. |volume=121 |issue= 4 |pages= 765–70 |year= 2003 |pmid= 14632194 |doi= 10.1046/j.1523-1747.2003.12494.x }}
*{{cite journal |author1=Gibson WT |author2=Pissios P |author3=Trombly DJ |author4=''et al.'' |title=Melanin-concentrating hormone receptor mutations and human obesity: functional analysis. |journal=Obes. Res. |volume=12 |issue= 5 |pages= 743–9 |year= 2004 |pmid= 15166293 |doi=10.1038/oby.2004.89 }}
*{{cite journal |author1=Hawes BE |author2=Green B |author3=O'Neill K |author4=''et al.'' |title=Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2. |journal=Obes. Res. |volume=12 |issue= 8 |pages= 1327–34 |year= 2004 |pmid= 15340116 |doi=10.1038/oby.2004.167 }}
*{{cite journal |author1=Collins JE |author2=Wright CL |author3=Edwards CA |author4=''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }}
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2998 | title = Melanin-Concentrating Hormone Receptors: MCH<sub>1</sub> | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
}}
{{Литература крај}}
{{-}}
{{G protein spregnuti receptori-lat}}
{{Neuropeptidni ligandi-lat}}

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[[Категорија:Г протеин спрегнути рецептори]]

Тренутна верзија на датум 7. април 2024. у 23:43

Melanin-koncentrirajući hormonski receptor 1
Identifikatori
Simboli MCHR1; GPR24; MCH1R; MGC32129; SLC1
Vanjski ID OMIM: 601751 MGI: 2180756 HomoloGene: 21097 IUPHAR: MCH1 GeneCards: MCHR1 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2847 207911
Ensembl ENSG00000128285 ENSMUSG00000050164
UniProt Q99705 Q3UY93
RefSeq (mRNA) NM_005297 NM_145132
RefSeq (protein) NP_005288 NP_660114
Lokacija (UCSC) Chr 22:
39.41 - 39.41 Mb		 Chr 15:
81.06 - 81.07 Mb
PubMed pretraga [1] [2]

Melanin-koncentrirajući hormonski receptor 1, takođe poznat kao MCH1, je jedan od ljudskih melanin-koncentrirajućih hormonskih receptora.[1]

Protein kodiran ovim genom je član G protein-spregnuti receptor familije 1. On je integralni protein membrane plazme koji vezuje melanin-koncentrirajući hormon. Ovaj receptor može da inhibira cAMP akumulaciju, i da stimuliše intracelularni kalcijum fluks. Smatra se da on učestvuje u neuronalnoj regulaciju konzumacije hrane. Mada je strukturno sličan sa somatostatin receptorima, ovaj protein ne vezuje somatostatin.[1]

Funkcija

[уреди | уреди извор]

MCH1 ima brojne funkcije, u koje se ubrajaju regulacija apetita,[2][3] kao i posredovanje stresa, strepnje i depresije.[4][5][6][7][8][9]

Selektivni Ligandi

[уреди | уреди извор]

Agonisti

[уреди | уреди извор]

Antagonisti

[уреди | уреди извор]

Vidi još

[уреди | уреди извор]

Literatura

[уреди | уреди извор]
  1. ^ а б „Entrez Gene: MCHR1 melanin-concentrating hormone receptor 1”. 
  2. ^ Luthin DR (2007). „Anti-obesity effects of small molecule melanin-concentrating hormone receptor 1 (MCHR1) antagonists”. Life Sciences. 81 (6): 423—40. PMID 17655875. doi:10.1016/j.lfs.2007.05.029. 
  3. ^ Rivera G, Bocanegra-García V, Galiano S, Cirauqui N, Ceras J, Pérez S, Aldana I, Monge A (2008). „Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity”. Current Medicinal Chemistry. 15 (10): 1025—43. PMID 18393860. doi:10.2174/092986708784049621. 
  4. ^ Hervieu G (2003). „Melanin-concentrating hormone functions in the nervous system: food intake and stress”. Expert Opinion on Therapeutic Targets. 7 (4): 495—511. PMID 12885269. doi:10.1517/14728222.7.4.495. 
  5. ^ Shimazaki T, Yoshimizu T, Chaki S (2006). „Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders”. CNS Drugs. 20 (10): 801—11. PMID 16999451. 
  6. ^ Hervieu GJ (2006). „Further insights into the neurobiology of melanin-concentrating hormone in energy and mood balances”. Expert Opinion on Therapeutic Targets. 10 (2): 211—29. PMID 16548771. doi:10.1517/14728222.10.2.211. 
  7. ^ Smith DG, Davis RJ, Rorick-Kehn L, Morin M, Witkin JM, McKinzie DL, Nomikos GG, Gehlert DR (2006). „Melanin-concentrating hormone-1 receptor modulates neuroendocrine, behavioral, and corticolimbic neurochemical stress responses in mice”. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31 (6): 1135—45. PMID 16205780. doi:10.1038/sj.npp.1300913. 
  8. ^ Roy M, David N, Cueva M, Giorgetti M (2007). „A study of the involvement of melanin-concentrating hormone receptor 1 (MCHR1) in murine models of depression”. Biological Psychiatry. 61 (2): 174—80. PMID 16934771. doi:10.1016/j.biopsych.2006.03.076. 
  9. ^ Saito Y, Nagasaki H (2008). „The melanin-concentrating hormone system and its physiological functions”. Results and Problems in Cell Differentiation. 46: 159—79. PMID 18227983. doi:10.1007/400_2007_052. 
  10. ^ Audinot V, Lahaye C, Suply T, Beauverger P, Rodriguez M, Galizzi JP, Fauchère JL, Boutin JA (2001). „[125I]-S36057: a new and highly potent radioligand for the melanin-concentrating hormone receptor”. British Journal of Pharmacology. 133 (3): 371—8. PMC 1572795 Слободан приступ. PMID 11375253. doi:10.1038/sj.bjp.0704085. 
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  15. ^ {{cite journal |vauthors=David DJ, Klemenhagen KC, Holick KA, Saxe MD, Mendez I, Santarelli L, Craig DA, Zhong H, Swanson CJ, Hegde LG, Ping XI, Dong D, Marzabadi MR, Gerald CP, Hen R |title=Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=321 |issue=1 |pages=237–48 |year=2007 |pmid=17237257 |doi=10.1124/jpet.106.109678 |url=}}
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Dodatna literatura

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