Bleeding: Difference between revisions

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{{short description|Loss of blood escaping from the circulatory system}}{{redirect2|Hemorrhage|Haemorrhage|the song named 'Hemorrhage' by [[Fuel (band)|Fuel]]|Hemorrhage (In My Hands)|the band named 'Hemorraghe'|Haemorrhage (band)}}
{{for multi|the voluntary extraction of blood|Bloodletting|other uses}}
{{short description|Loss of blood escaping from the circulatory system}}
{{Infobox medical condition (new)
| image = Bleeding finger.jpg
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Some medical conditions can also make patients susceptible to bleeding. These are conditions that affect the normal hemostatic (bleeding-control) functions of the body. Such conditions either are, or cause, [[bleeding diathesis|bleeding diatheses]]. [[Hemostasis]] involves several components. The main components of the hemostatic system include [[platelets]] and the [[blood coagulation|coagulation]] system.
 
[[Platelets]] are small blood components that form a plug in the blood vessel wall that stops bleeding. Platelets also produce a variety of substances that stimulate the production of a blood clot. One of the most common causes of increased bleeding risk is exposure to [[nonsteroidal anti-inflammatory drugs]] (NSAIDs). The prototype for these drugs is aspirin, which inhibits the production of thromboxane. NSAIDs (for example IbuprofinIbuprofen) inhibit the activation of [[platelets]], and thereby increase the risk of bleeding. The effect of aspirin is irreversible; therefore, the inhibitory effect of aspirin is present until the platelets have been replaced (about ten days). Other NSAIDs, such as "ibuprofen" (Motrin) and related drugs, are reversible and therefore, the effect on platelets is not as long-lived.{{cn|date=June 2022}}
 
There are several named coagulation factors that interact in a complex way to form blood clots, as discussed in the article on [[coagulation]]. Deficiencies of coagulation factors are associated with clinical bleeding. For instance, deficiency of Factor VIII causes classic [[hemophilia A]] while deficiencies of Factor IX cause "Christmas disease"([[hemophilia B]]). Antibodies to Factor VIII can also inactivate the Factor VII and precipitate bleeding that is very difficult to control. This is a rare condition that is most likely to occur in older patients and in those with [[autoimmune]] diseases. Another common bleeding disorder is [[Von Willebrand disease]]. It is caused by a deficiency or abnormal function of the "Von Willebrand" factor, which is involved in platelet activation. Deficiencies in other factors, such as factor XIII or factor VII are occasionally seen, but may not be associated with severe bleeding and are not as commonly diagnosed.
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==Management==
{{Main|Emergency_bleeding_control#External_wound_managementWound_management}}
{{For|the long process of regeneration of the body tissues|Wound healing|Wound bed preparation}}
 
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== See also ==
* [[Anaesthesia Trauma and Critical Care]]
* [[Aneurysm]]
* [[Autohaemorrhaging|Autohemorrhaging]]
* [[Anemia]]
* [[Coagulation]]
* [[Contusion]]
* [[Exsanguination]]
* [[Hematophagy|Hemophage]]
* [[Hemophilia]]
* [[Hematoma]]