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<br />- [[Glycopyrronium bromide]] (here under trade name Robinul), reducing secretions
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Paralysis, or temporary muscle relaxation with a [[neuromuscular blocker]], is an integral part of modern anaesthesia. The first drug used for this purpose was [[curare]], introduced in the 1940s, which has now been superseded by drugs with fewer side effects and, generally, shorter duration of action.<ref>Eger, Edmond I II; Saidman, Lawrence J.; Westhorpe, Rod N., eds. (2014). The Wondrous Story of Anaesthesia. Springer. p. 438. {{
[[Acetylcholine]], a natural [[neurotransmitter]] found at the [[neuromuscular junction]], causes muscles to contract when it is released from nerve endings. Muscle paralytic drugs work by preventing acetylcholine from attaching to its receptor. Paralysis of the muscles of respiration—the [[diaphragm (anatomy)|diaphragm]] and [[intercostal muscle]]s of the chest—requires that some form of artificial respiration be implemented. Because the muscles of the [[larynx]] are also paralysed, the airway usually needs to be protected by means of an [[endotracheal tube]].<ref name=":11" />
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