MTEP: Difference between revisions

}}</ref><ref>{{Cite journal | last1 = Szydlowska | first1 = K. | last2 = Kaminska | first2 = B. | last3 = Baude | first3 = A. | last4 = Parsons | first4 = C. G. | last5 = Danysz | first5 = W. | title = Neuroprotective activity of selective mGlu1 and mGlu5 antagonists in vitro and in vivo | doi = 10.1016/j.ejphar.2006.09.061 | journal = European Journal of Pharmacology | volume = 554 | issue = 1 | pages = 18–29 | year = 2007 | pmid = 17109843}}</ref> [[antidepressant]],<ref>{{Cite journal | last1 = Pałucha | first1 = A. | last2 = Brański | first2 = P. | last3 = Szewczyk | first3 = B. | last4 = Wierońska | first4 = J. M. | last5 = Kłak | first5 = K. | last6 = Pilc | first6 = A. | doi = 10.1016/j.pbb.2005.06.015 | title = Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist | journal = Pharmacology Biochemistry and Behavior | volume = 81 | issue = 4 | pages = 901–6 | year = 2005 | pmid = 16040106| s2cid = 42920507 }}</ref><ref>{{Cite journal | last1 = Molina-Hernández | first1 = M. | last2 = Tellez-Alcántara | first2 = N. P. | last3 = Pérez-García | first3 = J. N. | last4 = Olivera-Lopez | first4 = J. I. N. | last5 = Jaramillo | first5 = M. T. | title = Antidepressant-like and anxiolytic-like actions of the mGlu5 receptor antagonist MTEP, microinjected into lateral septal nuclei of male Wistar rats | doi = 10.1016/j.pnpbp.2006.04.022 | journal = Progress in Neuro-Psychopharmacology and Biological Psychiatry | volume = 30 | issue = 6 | pages = 1129–1135 | year = 2006 | pmid = 16759778| s2cid = 45937198 }}</ref><ref>{{Cite journal | last1 = Li | first1 = X. | last2 = Need | first2 = A. B. | last3 = Baez | first3 = M. | last4 = Witkin | first4 = J. M. | title = Metabotropic Glutamate 5 Receptor Antagonism is Associated with Antidepressant-Like Effects in Mice | doi = 10.1124/jpet.106.103143 | journal = Journal of Pharmacology and Experimental Therapeutics | volume = 319 | issue = 1 | pages = 254–259 | year = 2006 | pmid = 16803860| s2cid = 14632318 | url = https://semanticscholar.org/paper/8dbbcdeedc467c91f688da125b82db7cf24fe2e8 }}</ref><ref>{{Cite journal | last1 = Belozertseva | first1 = I. | last2 = Kos | first2 = T. | last3 = Popik | first3 = P. | last4 = Danysz | first4 = W. | last5 = Bespalov | first5 = A. | title = Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests | doi = 10.1016/j.euroneuro.2006.03.002 | journal = European Neuropsychopharmacology | volume = 17 | issue = 3 | pages = 172–179 | year = 2007 | pmid = 16630709| s2cid = 2420850 }}</ref> [[analgesic]],<ref>{{Cite journal | last1 = Zhu | first1 = C. Z. | last2 = Wilson | first2 = S. G. | last3 = Mikusa | first3 = J. P. | last4 = Wismer | first4 = C. T. | last5 = Gauvin | first5 = D. M. | last6 = Lynch Jj | first6 = J. J. | last7 = Wade | first7 = C. L. | last8 = Decker | first8 = M. W. | last9 = Honore | first9 = P. | doi = 10.1016/j.ejphar.2004.11.005 | title = Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities | journal = European Journal of Pharmacology | volume = 506 | issue = 2 | pages = 107–118 | year = 2004 | pmid = 15588730}}</ref><ref>{{Cite journal | last1 = Varty | first1 = G. B. | last2 = Grilli | first2 = M. | last3 = Forlani | first3 = A. | last4 = Fredduzzi | first4 = S. | last5 = Grzelak | first5 = M. E. | last6 = Guthrie | first6 = D. H. | last7 = Hodgson | first7 = R. A. | last8 = Lu | first8 = S. X. | last9 = Nicolussi | first9 = E. | doi = 10.1007/s00213-005-2143-4 | last10 = Pond | first10 = A. J. | last11 = Parker | first11 = E. M. | last12 = Hunter | first12 = J. C. | last13 = Higgins | first13 = G. A. | last14 = Reggiani | first14 = A. | last15 = Bertorelli | first15 = R. | title = The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: A comparison of efficacy and side-effect profiles | journal = Psychopharmacology | volume = 179 | issue = 1 | pages = 207–217 | year = 2005 | pmid = 15682298| s2cid = 21807900 }}</ref> and [[anxiolytic]] effects but with either similar or higher [[efficacy]] depending on the test used.<ref>{{Cite journal | last1 = Klodzinska | first1 = A. | last2 = Tatarczyńska | first2 = E. | last3 = Chojnacka-Wójcik | first3 = E. | last4 = Nowak | first4 = G. | last5 = Cosford | first5 = N. D. P. | last6 = Pilc | first6 = A. | doi = 10.1016/j.neuropharm.2004.04.013 | title = Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABAA signaling | journal = Neuropharmacology | volume = 47 | issue = 3 | pages = 342–350 | year = 2004 | pmid = 15275823| s2cid = 54432014 }}</ref><ref>{{Cite journal | last1 = Busse | first1 = C. S. | last2 = Brodkin | first2 = J. | last3 = Tattersall | first3 = D. | last4 = Anderson | first4 = J. J. | last5 = Warren | first5 = N. | last6 = Tehrani | first6 = L. | last7 = Bristow | first7 = L. J. | last8 = Varney | first8 = M. A. | last9 = Cosford | first9 = N. D. | doi = 10.1038/sj.npp.1300540 | title = The Behavioral Profile of the Potent and Selective mGlu5 Receptor Antagonist 3-\(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in Rodent Models of Anxiety | journal = Neuropsychopharmacology | volume = 29 | issue = 11 | pages = 1971–1979 | year = 2004 | pmid = 15305166| doi-access = free }}</ref><ref>{{Cite journal | last1 = Pietraszek | first1 = M. G. | last2 = Sukhanov | first2 = I. | last3 = MacIejak | first3 = P. | last4 = Szyndler | first4 = J. | last5 = Gravius | first5 = A. | last6 = Wisłowska | first6 = A. | last7 = Płaźnik | first7 = A. | last8 = Bespalov | first8 = A. Y. | last9 = Danysz | first9 = W. | doi = 10.1016/j.ejphar.2005.03.028 | title = Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats | journal = European Journal of Pharmacology | volume = 514 | issue = 1 | pages = 25–34 | year = 2005 | pmid = 15878321}}</ref><ref>{{Cite journal | last1 = Stachowicz | first1 = K. | last2 = Gołembiowska | first2 = K. | last3 = Sowa | first3 = M. | last4 = Nowak | first4 = G. | last5 = Chojnacka-Wójcik | first5 = E. | last6 = Pilc | first6 = A. | doi = 10.1016/j.neuropharm.2007.08.002 | title = Anxiolytic-like action of MTEP expressed in the conflict drinking Vogel test in rats is serotonin dependent | journal = Neuropharmacology | volume = 53 | issue = 6 | pages = 741–748 | year = 2007 | pmid = 17870136| s2cid = 24833690 }}</ref>

MTEP also has similar efficacy to MPEP in reducing the symptoms of [[morphine]] [[Drug withdrawal|withdrawal]],<ref>{{cite journal |vauthors=Pałucha A, Brański P, Pilc A |title=Selective mGlu5 receptor antagonist MTEP attenuates naloxone-induced morphine with-drawal symptoms |journal=Pol J Pharmacol |volume=56 |issue=6 |pages=863–6 |year=2004 |pmid=15662102 |url=http://www.if-pan.krakow.pl/pjp/pdf/2004/6_863.pdf}}</ref><ref>{{cite journal |vauthors=Rasmussen K, Martin H, Berger JE, Seager MA |title=The mGlu5 receptor antagonists MPEP and MTEP attenuate behavioral signs of morphine withdrawal and morphine-withdrawal-induced activation of locus coeruleus neurons in rats |journal=Neuropharmacology |volume=48 |issue=2 |pages=173–80 |date=February 2005 |pmid=15695156 |doi=10.1016/j.neuropharm.2004.09.010 |s2cid=13552709 }}</ref><ref>{{cite journal |vauthors=Kotlinska J, Bochenski M |title=Comparison of the effects of mGluR1 and mGluR5 antagonists on the expression of behavioral sensitization to the locomotor effect of morphine and the morphine withdrawal jumping in mice |journal=Eur. J. Pharmacol. |volume=558 |issue=1–3 |pages=113–8 |date=March 2007 |pmid=17222405 |doi=10.1016/j.ejphar.2006.11.067 }}</ref> and has anti-addictive effects in a variety of animal models, both reducing ethanol self-administration,<ref>{{cite journal |vauthors=Cowen MS, Djouma E, Lawrence AJ |title=The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems |journal=J. Pharmacol. Exp. Ther. |volume=315 |issue=2 |pages=590–600 |date=November 2005 |pmid=16014750 |doi=10.1124/jpet.105.090449 |s2cid=11501029 }}</ref><ref>{{cite journal |vauthors=Cowen MS, Krstew E, Lawrence AJ |title=Assessing appetitive and consummatory phases of ethanol self-administration in C57BL/6J mice under operant conditions: regulation by mGlu5 receptor antagonism |journal=Psychopharmacology |volume=190 |issue=1 |pages=21–9 |date=January 2007 |pmid=17096086 |doi=10.1007/s00213-006-0583-0 |s2cid=19977179 }}</ref><ref>{{cite journal |vauthors=Adams CL, Cowen MS, Short JL, Lawrence AJ |title=Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats |journal=Int. J. Neuropsychopharmacol. |volume=11 |issue=2 |pages=229–41 |date=March 2008 |pmid=17517168 |doi=10.1017/S1461145707007845 |doi-access=free }}</ref><ref>{{cite journal |vauthors=Kotlinska J, Bochenski M |title=The influence of various glutamate receptors antagonists on anxiety-like effect of ethanol withdrawal in a plus-maze test in rats |journal=Eur. J. Pharmacol. |volume=598 |issue=1–3 |pages=57–63 |date=November 2008 |pmid=18838071 |doi=10.1016/j.ejphar.2008.09.026 }}</ref> and also decreasing the addictive effects of [[nicotine]], [[cocaine]] and [[methamphetamine]].<ref>{{cite journal |vauthors=Dravolina OA, Danysz W, Bespalov AY |title=Effects of group I metabotropic glutamate receptor antagonists on the behavioral sensitization to motor effects of cocaine in rats |journal=Psychopharmacology |volume=187 |issue=4 |pages=397–404 |date=September 2006 |pmid=16896963 |doi=10.1007/s00213-006-0440-1 |s2cid=21231365 }}</ref><ref>{{cite journal |vauthors=Palmatier MI, Liu X, Donny EC, Caggiula AR, Sved AF |title=Metabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotine |journal=Neuropsychopharmacology |volume=33 |issue=9 |pages=2139–47 |date=August 2008 |pmid=18046312 |doi=10.1038/sj.npp.1301623 |pmc=2812904}}</ref><ref>{{cite journal |vauthors=Gass JT, Osborne MP, Watson NL, Brown JL, Olive MF |title=mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats |journal=Neuropsychopharmacology |volume=34 |issue=4 |pages=820–33 |date=March 2009 |pmid=18800068 |pmc=2669746 |doi=10.1038/npp.2008.140 }}</ref><ref>{{cite journal |vauthors=Osborne MP, Olive MF |title=A role for mGluR5 receptors in intravenous methamphetamine self-administration |journal=Ann. N. Y. Acad. Sci. |volume=1139 |pages=206–11 |date=October 2008 |issue=1 |pmid=18991866 |doi=10.1196/annals.1432.034 |bibcode=2008NYASA1139..206O |s2cid=207012906 }}</ref><ref>{{cite journal |vauthors=Martin-Fardon R, Baptista MA, Dayas CV, Weiss F |title=Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer |journal=J. Pharmacol. Exp. Ther. |volume=329 |issue=3 |pages=1084–90 |date=June 2009 |pmid=19258516 |doi=10.1124/jpet.109.151357 |pmc=2683783}}</ref>