MTEP: Difference between revisions

 

MTEP also has similar efficacy to MPEP in reducing the symptoms of [[morphine]] [[Drug withdrawal|withdrawal]],<ref>{{cite journal |vauthors=Pałucha A, Brański P, Pilc A |title=Selective mGlu5 receptor antagonist MTEP attenuates naloxone-induced morphine with-drawal symptoms |journal=Pol J Pharmacol |volume=56 |issue=6 |pages=863–6 |year=2004 |pmid=15662102 |doi= |url=http://www.if-pan.krakow.pl/pjp/pdf/2004/6_863.pdf}}</ref><ref>{{cite journal |vauthors=Rasmussen K, Martin H, Berger JE, Seager MA |title=The mGlu5 receptor antagonists MPEP and MTEP attenuate behavioral signs of morphine withdrawal and morphine-withdrawal-induced activation of locus coeruleus neurons in rats |journal=Neuropharmacology |volume=48 |issue=2 |pages=173–80 |date=February 2005 |pmid=15695156 |doi=10.1016/j.neuropharm.2004.09.010 |url=}}</ref><ref>{{cite journal |vauthors=Kotlinska J, Bochenski M |title=Comparison of the effects of mGluR1 and mGluR5 antagonists on the expression of behavioral sensitization to the locomotor effect of morphine and the morphine withdrawal jumping in mice |journal=Eur. J. Pharmacol. |volume=558 |issue=1-3 |pages=113–8 |date=March 2007 |pmid=17222405 |doi=10.1016/j.ejphar.2006.11.067 |url=}}</ref> and has anti-addictive effects in a variety of animal models, both reducing ethanol self-administration,<ref>{{cite journal |vauthors=Cowen MS, Djouma E, Lawrence AJ |title=The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems |journal=J. Pharmacol. Exp. Ther. |volume=315 |issue=2 |pages=590–600 |date=November 2005 |pmid=16014750 |doi=10.1124/jpet.105.090449 |url=}}</ref><ref>{{cite journal |vauthors=Cowen MS, Krstew E, Lawrence AJ |title=Assessing appetitive and consummatory phases of ethanol self-administration in C57BL/6J mice under operant conditions: regulation by mGlu5 receptor antagonism |journal=Psychopharmacology (Berl.) |volume=190 |issue=1 |pages=21–9 |date=January 2007 |pmid=17096086 |doi=10.1007/s00213-006-0583-0 |url=}}</ref><ref>{{cite journal |vauthors=Adams CL, Cowen MS, Short JL, Lawrence AJ |title=Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats |journal=Int. J. Neuropsychopharmacol. |volume=11 |issue=2 |pages=229–41 |date=March 2008 |pmid=17517168 |doi=10.1017/S1461145707007845 |url=}}</ref><ref>{{cite journal |vauthors=Kotlinska J, Bochenski M |title=The influence of various glutamate receptors antagonists on anxiety-like effect of ethanol withdrawal in a plus-maze test in rats |journal=Eur. J. Pharmacol. |volume=598 |issue=1-3 |pages=57–63 |date=November 2008 |pmid=18838071 |doi=10.1016/j.ejphar.2008.09.026 |url=}}</ref> and also decreasing the addictive effects of [[nicotine]], [[cocaine]] and [[methamphetamine]].<ref>{{cite journal |vauthors=Dravolina OA, Danysz W, Bespalov AY |title=Effects of group I metabotropic glutamate receptor antagonists on the behavioral sensitization to motor effects of cocaine in rats |journal=Psychopharmacology (Berl.) |volume=187 |issue=4 |pages=397–404 |date=September 2006 |pmid=16896963 |doi=10.1007/s00213-006-0440-1 |url=}}</ref><ref>{{cite journal |vauthors=Palmatier MI, Liu X, Donny EC, Caggiula AR, Sved AF |title=Metabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotine |journal=Neuropsychopharmacology |volume=33 |issue=9 |pages=2139–47 |date=August 2008 |pmid=18046312 |doi=10.1038/sj.npp.1301623 |url= |pmc=2812904}}</ref><ref>{{cite journal |vauthors=Gass JT, Osborne MP, Watson NL, Brown JL, Olive MF |title=mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats |journal=Neuropsychopharmacology |volume=34 |issue=4 |pages=820–33 |date=March 2009 |pmid=18800068 |pmc=2669746 |doi=10.1038/npp.2008.140 |url=}}</ref><ref>{{cite journal |vauthors=Osborne MP, Olive MF |title=A role for mGluR5 receptors in intravenous methamphetamine self-administration |journal=Ann. N. Y. Acad. Sci. |volume=1139 |issue= |pages=206–11 |date=October 2008 |pmid=18991866 |doi=10.1196/annals.1432.034 |url=}}</ref><ref>{{cite journal |vauthors=Martin-Fardon R, Baptista MA, Dayas CV, Weiss F |title=Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer |journal=J. Pharmacol. Exp. Ther. |volume=329 |issue=3 |pages=1084–90 |date=June 2009 |pmid=19258516 |doi=10.1124/jpet.109.151357 |url= |pmc=2683783}}</ref>

 

==References==