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MTEP is both more [[Potency (pharmacology)|potent]] and more [[Functional selectivity|selective]] than [[2-Methyl-6-(phenylethynyl)pyridine|MPEP]] as a mGluR5 antagonist,<ref>{{cite journal | vauthors = Lea PM, Faden AI | title = Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP | journal = CNS Drug Reviews | volume = 12 | issue = 2 | pages = 149–166 | year = 2006 | pmid = 16958988 | pmc = 6494124 | doi = 10.1111/j.1527-3458.2006.00149.x }}</ref> and produces similar [[neuroprotective]],<ref>{{cite journal | vauthors = Lea PM, Movsesyan VA, Faden AI | title = Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors | journal = British Journal of Pharmacology | volume = 145 | issue = 4 | pages = 527–534 | date = June 2005 | pmid = 15821750 | pmc = 1576169 | doi = 10.1038/sj.bjp.0706219 }}</ref><ref>{{cite journal | vauthors = Domin H, Kajta M, Smiałowska M | title = Neuroprotective effects of MTEP, a selective mGluR5 antagonists and neuropeptide Y on the kainate-induced toxicity in primary neuronal cultures | journal = Pharmacological Reports | volume = 58 | issue = 6 | pages = 846–858 | year = 2006 | pmid = 17220542 }}</ref><ref>{{cite journal | vauthors = Szydlowska K, Kaminska B, Baude A, Parsons CG, Danysz W | title = Neuroprotective activity of selective mGlu1 and mGlu5 antagonists in vitro and in vivo | journal = European Journal of Pharmacology | volume = 554 | issue = 1 | pages = 18–29 | date = January 2007 | pmid = 17109843 | doi = 10.1016/j.ejphar.2006.09.061 }}</ref> [[antidepressant]],<ref>{{cite journal | vauthors = Pałucha A, Brański P, Szewczyk B, Wierońska JM, Kłak K, Pilc A | title = Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist | journal = Pharmacology, Biochemistry, and Behavior | volume = 81 | issue = 4 | pages = 901–906 | date = August 2005 | pmid = 16040106 | doi = 10.1016/j.pbb.2005.06.015 | s2cid = 42920507 }}</ref><ref>{{cite journal | vauthors = Molina-Hernández M, Tellez-Alcántara NP, Pérez-García J, Olivera-Lopez JI, Jaramillo MT | title = Antidepressant-like and anxiolytic-like actions of the mGlu5 receptor antagonist MTEP, microinjected into lateral septal nuclei of male Wistar rats | journal = Progress in Neuro-Psychopharmacology & Biological Psychiatry | volume = 30 | issue = 6 | pages = 1129–1135 | date = August 2006 | pmid = 16759778 | doi = 10.1016/j.pnpbp.2006.04.022 | s2cid = 45937198 }}</ref><ref>{{cite journal | vauthors = Li X, Need AB, Baez M, Witkin JM | title = Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 319 | issue = 1 | pages = 254–259 | date = October 2006 | pmid = 16803860 | doi = 10.1124/jpet.106.103143 | s2cid = 14632318 }}</ref><ref>{{cite journal | vauthors = Belozertseva IV, Kos T, Popik P, Danysz W, Bespalov AY | title = Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests | journal = European Neuropsychopharmacology | volume = 17 | issue = 3 | pages = 172–179 | date = February 2007 | pmid = 16630709 | doi = 10.1016/j.euroneuro.2006.03.002 | s2cid = 2420850 }}</ref> [[analgesic]],<ref>{{cite journal | vauthors = Zhu CZ, Wilson SG, Mikusa JP, Wismer CT, Gauvin DM, Lynch JJ, Wade CL, Decker MW, Honore P | display-authors = 6 | title = Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities | journal = European Journal of Pharmacology | volume = 506 | issue = 2 | pages = 107–118 | date = December 2004 | pmid = 15588730 | doi = 10.1016/j.ejphar.2004.11.005 }}</ref><ref>{{cite journal | vauthors = Varty GB, Grilli M, Forlani A, Fredduzzi S, Grzelak ME, Guthrie DH, Hodgson RA, Lu SX, Nicolussi E, Pond AJ, Parker EM, Hunter JC, Higgins GA, Reggiani A, Bertorelli R | display-authors = 6 | title = The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles | journal = Psychopharmacology | volume = 179 | issue = 1 | pages = 207–217 | date = April 2005 | pmid = 15682298 | doi = 10.1007/s00213-005-2143-4 | s2cid = 21807900 }}</ref> and [[anxiolytic]] effects but with either similar or higher [[efficacy]] depending on the test used.<ref>{{cite journal | vauthors = Klodzinska A, Tatarczyńska E, Chojnacka-Wójcik E, Nowak G, Cosford ND, Pilc A | title = Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling | journal = Neuropharmacology | volume = 47 | issue = 3 | pages = 342–350 | date = September 2004 | pmid = 15275823 | doi = 10.1016/j.neuropharm.2004.04.013 | s2cid = 54432014 }}</ref><ref>{{cite journal | vauthors = Busse CS, Brodkin J, Tattersall D, Anderson JJ, Warren N, Tehrani L, Bristow LJ, Varney MA, Cosford ND | display-authors = 6 | title = The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety | journal = Neuropsychopharmacology | volume = 29 | issue = 11 | pages = 1971–1979 | date = November 2004 | pmid = 15305166 | doi = 10.1038/sj.npp.1300540 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Pietraszek M, Sukhanov I, Maciejak P, Szyndler J, Gravius A, Wisłowska A, Płaźnik A, Bespalov AY, Danysz W | display-authors = 6 | title = Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats | journal = European Journal of Pharmacology | volume = 514 | issue = 1 | pages = 25–34 | date = May 2005 | pmid = 15878321 | doi = 10.1016/j.ejphar.2005.03.028 }}</ref><ref>{{cite journal | vauthors = Stachowicz K, Gołembiowska K, Sowa M, Nowak G, Chojnacka-Wójcik E, Pilc A | title = Anxiolytic-like action of MTEP expressed in the conflict drinking Vogel test in rats is serotonin dependent | journal = Neuropharmacology | volume = 53 | issue = 6 | pages = 741–748 | date = November 2007 | pmid = 17870136 | doi = 10.1016/j.neuropharm.2007.08.002 | s2cid = 24833690 }}</ref>
MTEP also has similar efficacy to MPEP in reducing the symptoms of [[morphine]] [[Drug withdrawal|withdrawal]],<ref>{{cite journal | vauthors = Pałucha A, Brański P, Pilc A | title = Selective mGlu5 receptor antagonist MTEP attenuates naloxone-induced morphine withdrawal symptoms | journal = Polish Journal of Pharmacology | volume = 56 | issue = 6 | pages = 863–866 | year = 2004 | pmid = 15662102 | url = http://www.if-pan.krakow.pl/pjp/pdf/2004/6_863.pdf }}</ref><ref>{{cite journal | vauthors = Rasmussen K, Martin H, Berger JE, Seager MA | title = The mGlu5 receptor antagonists MPEP and MTEP attenuate behavioral signs of morphine withdrawal and morphine-withdrawal-induced activation of locus coeruleus neurons in rats | journal = Neuropharmacology | volume = 48 | issue = 2 | pages = 173–180 | date = February 2005 | pmid = 15695156 | doi = 10.1016/j.neuropharm.2004.09.010 | s2cid = 13552709 }}</ref><ref>{{cite journal | vauthors = Kotlinska J, Bochenski M | title = Comparison of the effects of mGluR1 and mGluR5 antagonists on the expression of behavioral sensitization to the locomotor effect of morphine and the morphine withdrawal jumping in mice | journal = European Journal of Pharmacology | volume = 558 | issue = 1–3 | pages = 113–118 | date = March 2007 | pmid = 17222405 | doi = 10.1016/j.ejphar.2006.11.067 }}</ref> and has anti-addictive effects in a variety of animal models, both reducing ethanol self-administration,<ref>{{cite journal | vauthors = Cowen MS, Djouma E, Lawrence AJ | title = The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 315 | issue = 2 | pages = 590–600 | date = November 2005 | pmid = 16014750 | doi = 10.1124/jpet.105.090449 | s2cid = 11501029 }}</ref><ref>{{cite journal | vauthors = Cowen MS, Krstew E, Lawrence AJ | title = Assessing appetitive and consummatory phases of ethanol self-administration in C57BL/6J mice under operant conditions: regulation by mGlu5 receptor antagonism | journal = Psychopharmacology | volume = 190 | issue = 1 | pages = 21–29 | date = January 2007 | pmid = 17096086 | doi = 10.1007/s00213-006-0583-0 | s2cid = 19977179 }}</ref><ref>{{cite journal | vauthors = Adams CL, Cowen MS, Short JL, Lawrence AJ | title = Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats | journal = The International Journal of Neuropsychopharmacology | volume = 11 | issue = 2 | pages = 229–241 | date = March 2008 | pmid = 17517168 | doi = 10.1017/S1461145707007845 | doi-access = free | hdl = 11343/32923 | hdl-access = free }}</ref><ref>{{cite journal | vauthors = Kotlinska J, Bochenski M | title = The influence of various glutamate receptors antagonists on anxiety-like effect of ethanol withdrawal in a plus-maze test in rats | journal = European Journal of Pharmacology | volume = 598 | issue = 1–3 | pages = 57–63 | date = November 2008 | pmid = 18838071 | doi = 10.1016/j.ejphar.2008.09.026 }}</ref> and also decreasing the addictive effects of [[nicotine]], [[cocaine]] and [[methamphetamine]].<ref>{{cite journal | vauthors = Dravolina OA, Danysz W, Bespalov AY | title = Effects of group I metabotropic glutamate receptor antagonists on the behavioral sensitization to motor effects of cocaine in rats | journal = Psychopharmacology | volume = 187 | issue = 4 | pages = 397–404 | date = September 2006 | pmid = 16896963 | doi = 10.1007/s00213-006-0440-1 | s2cid = 21231365 }}</ref><ref>{{cite journal | vauthors = Palmatier MI, Liu X, Donny EC, Caggiula AR, Sved AF | title = Metabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotine | journal = Neuropsychopharmacology | volume = 33 | issue = 9 | pages = 2139–2147 | date = August 2008 | pmid = 18046312 | pmc = 2812904 | doi = 10.1038/sj.npp.1301623 }}</ref><ref>{{cite journal | vauthors = Gass JT, Osborne MP, Watson NL, Brown JL, Olive MF | title = mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats | journal = Neuropsychopharmacology | volume = 34 | issue = 4 | pages = 820–833 | date = March 2009 | pmid = 18800068 | pmc = 2669746 | doi = 10.1038/npp.2008.140 }}</ref><ref>{{cite journal | vauthors = Osborne MP, Olive MF | title = A role for mGluR5 receptors in intravenous methamphetamine self-administration | journal = Annals of the New York Academy of Sciences | volume = 1139 | issue = 1 | pages = 206–211 | date = October 2008 | pmid = 18991866 | doi = 10.1196/annals.1432.034 | s2cid = 207012906 | bibcode = 2008NYASA1139..206O }}</ref><ref>{{cite journal | vauthors = Martin-Fardon R, Baptista MA, Dayas CV, Weiss F | title = Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 329 | issue = 3 | pages = 1084–1090 | date = June 2009 | pmid = 19258516 | pmc = 2683783 | doi = 10.1124/jpet.109.151357 }}</ref>
== See also ==
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