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Birth of the United States of America''. Foundation, Malaga, pages 49, 57–65, 70–75, 150, 207</ref> [[Pierre Laclède]] and [[Auguste Chouteau]], all from [[New Orleans]]. They named it for king [[Louis IX of France]], and it quickly became the regional center of the French [[Illinois Country]]. In 1764, France was defeated in the [[Seven Years' War]]t and was forced o cede its territory east of the Mississippi to Great Britain. It ceded its nominal claim to areas west of the river to [[Louisiana (New Spain)|Spain]]. In 1800, Spain [[retroceded]] Louisiana to France. Three years later, [[Napoleon]] gave up on North America and sold the territory to the United States as part of the [[Louisiana Purchase]].<ref>{{cite web|url=http://www.britannica.com/EBchecked/topic/349302/Louisiana-Purchase|title=Louisiana Purchase - United States history|website=Britannica.com|access-date=August 10, 2017|archive-url=https://web.archive.org/web/20150501010249/http://www.britannica.com/EBchecked/topic/349302/Louisiana-Purchase|archive-date=May 1, 2015|url-status=live}}</ref>
The city was the point of embarkation for the [[Corps of Discovery]] on the United States' sponsored [[Lewis and Clark Expedition]] to explore the Louisiana Purchase. In the 19th century, St. Louis developed as a major port on the Mississippi River; from [[1870 United States census|1870]] until the [[1920 United States census|1920 census]], it was the fourth-largest city in the country. It [[urban secession|separated]] from [[St. Louis County, Missouri|St. Louis County]] in 1877, becoming an [[Independent city (United States)|independent city]] and limiting its political boundaries. In 1904, it hosted the [[Louisiana Purchase Exposition]] (also known as the World's Fair) and the [[1904 Summer Olympics|Summer Olympics]].
A [[global city]] with a metropolitan GDP of more than $160 billion in 2017,<ref>{{Cite web|url=https://www.bea.gov/iTable/index_regional.cfm|title=Regional Data - GDP & Personal Income|website=Bureau of Economic Analysis|access-date=July 5, 2017|archive-url=https://web.archive.org/web/20180702122229/https://www.bea.gov/iTable/index_regional.cfm|archive-date=July 2, 2018|url-status=live}}</ref> metropolitan St. Louis has a diverse economy with strengths in the service, manufacturing, trade, transportation, and tourism industries. It is home to eight [[Fortune 500]] companies. Major companies headquartered or with significant operations in the city include [[Ameren|Ameren Corporation]], [[Peabody Energy]], [[Nestlé Purina PetCare]], [[Anheuser-Busch]], [[Wells Fargo Advisors]], [[Stifel|Stifel Financial]], [[Spire Inc|Spire, Inc.]], [[MilliporeSigma]], [[FleishmanHillard]], [[Square, Inc.]], [[Anthem (company)|Anthem BlueCross and Blue Shield]], [[Centene Corporation]], and [[Express Scripts]]. Federal agencies include [[Federal Reserve Bank of St. Louis]], [[United States Department of Agriculture|U.S. Department of Agriculture]] offices, and [[National Geospatial-Intelligence Agency]], which is developing a new headquarters here.
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