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Line 3: ==Composition== Tonofilaments are [[keratin]] [[intermediate filaments]] that ~~makes~~make up tonofibrils in the epithelial tissue. In epithelial cells, tonofilaments loop through desmosomes. Electron microscopy has advanced now to illustrate the tonofilaments more clearly.<ref name=":0" /> [[File:Chiton epidermis TEM.jpg\|thumb\|alt=Chiton epidermis TEM\|[[Transmission electron micrograph]] depicting tonofilaments, labeled tf, running longitudinally within the dorsal epidermal cells of the [[girdle (chiton)\|girdle]] of a [[chiton]]]] The protein [[filaggrin]] is believed to be synthesized as a giant [[precursor protein]], profilaggrin (>400 kDA in humans). When filaggrin binds to keratin intermediate filaments, the keratin aggregates into macrofibrils.<ref name=":1">{{Cite journal\|title = Filaggrin in the frontline: role in skin barrier function and disease\|journal = J Cell Sci\|date = 2009-05-01\|issn = 0021-9533\|pmc = 2721001\|pmid = 19386895\|pages = 1285–1294\|volume = 122\|issue = 9\|doi = 10.1242/jcs.033969\|first1 = Aileen\|last1 = Sandilands\|first2 = Calum\|last2 = Sutherland\|first3 = Alan D.\|last3 = Irvine\|first4 = W. H. Irwin\|last4 = McLean}}</ref>

Tonofibril: Difference between revisions