(−)-beta-pinene synthase: Difference between revisions

| Name = (-−)-betaβ-pinene synthase

| EC_number = 4.2.3.120

| CAS_number =

| GO_codeimage =

| imagewidth =

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'''(-−)-betaβ-pinenePinene synthase''' ({{EC number|4.2.3.120}}, ''beta'β-geraniolene synthase''', '''(-−)-(1S1''S'',5S5''S'')-pinene synthase''', '''geranyldiphosphate diphosphate lyase (pinene forming)''') is an [[enzyme]] with system[[List of enzymes|systematic name]] '''geranyl-diphosphate diphosphate-lyase ([cyclizing, (-−)-betaβ-pinene-forming)]'''.<ref>{{cite journal | vauthors = Croteau RB, Wheeler CJ, Cane DE, Ebert R, Ha HJ | title = Isotopically sensitive branching in the formation of cyclic monoterpenes: proof that (-–)-&alpha;α-pinene and (-–)-&beta;β-pinene are synthesized by the same monoterpene cyclase via deprotonation of a common intermediate |author journal = Croteau, R.B., Wheeler, C.J.,Biochemistry Cane,| D.E., Ebert, R. and Ha, H.J. |journalvolume = Biochemistry26 |year issue = 198717 |volume pages = 265383–9 |pages date = 5383–5389August 1987 | pmid = 3314988 |issue=17 |doi = 10.1021/bi00391a025 }}</ref><ref>{{cite journal | vauthors = Croteau R, Satterwhite DM | title = Biosynthesis of monoterpenes. Stereochemical implications of acyclic and monocyclic olefin formation by (+)- and (-–)-pinene cyclases from sage |author journal = Croteau,The R.Journal andof Satterwhite,Biological D.M.Chemistry |journal volume = J.264 Biol.| Chem.issue = 26 |year pages = 15309–15 | date = September 1989 |volume doi = 26410.1016/S0021-9258(19)84827-5 |pages doi-access = 15309–15315free | pmid = 2768265 |issue=26}}</ref><ref>{{cite journal | vauthors = Croteau R, Satterwhite DM, Cane DE, Chang CC | title = Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (-–)-linalyl pyrophosphate to (+)- and (-–)-pinene and (+)- and (-–)-camphene |author journal = Croteau,The R.,Journal Satterwhite,of D.M.,Biological Cane,Chemistry D.E.| andvolume Chang,= C.C.263 |journal issue = J.21 Biol.| Chem.pages = 10063–71 |year date = July 1988 |volume doi = 26310.1016/S0021-9258(19)81477-1 |pages doi-access = 10063–10071free | pmid = 3392006 |issue=21}}</ref><ref>{{cite journal | vauthors = Pyun HJ, Wagschal KC, Jung DI, Coates RM, Croteau R | title = Stereochemistry of the proton elimination in the formation of (+)- and (-–)-&alpha;α-pinene by monoterpene cyclases from sage (''Salvia officinalis'') |author journal = Pyun,Archives H.J.,of Wagschal, K.C., Jung, D.I., Coates, R.M.Biochemistry and Croteau, R.Biophysics |journal volume = Arch.308 Biochem.| Biophys. |yearissue = 19942 |volume pages = 308488–96 |pages date = 488–496February 1994 | pmid = 8109979 | doi = 10.1006/abbi.1994.1069 |issue=2}}</ref><ref>{{cite journal | vauthors = Lu S, Xu R, Jia JW, Pang J, Matsuda SP, Chen XY | title = Cloning and functional characterization of a &beta;β-pinene synthase from ''Artemisia annua'' that shows a circadian pattern of expression |author journal = Lu,Plant S.,Physiology Xu,| R.,volume Jia,= J.W.,130 Pang,| J.,issue Matsuda,= S.P.1 and| Chen, X.Y. |journalpages = Plant477–86 Physiol.| |yeardate = September 2002 |volume pmid = 13012226526 |pages = 477–486 |pmidpmc = 12226526166579 | doi = 10.1104/pp.006544 |issue=1}}</ref><ref>{{cite journal | vauthors = Gijzen M, Lewinsohn E, Croteau R | title = Characterization of the constitutive and wound-inducible monoterpene cyclases of grand fir (''Abies grandis'') |author journal = Gijzen,Archives M.,of Lewinsohn, E.Biochemistry and Croteau, R.Biophysics |journal volume = Arch.289 Biochem.| Biophys. |yearissue = 19912 |volume pages = 289267–73 |pages date = 267–273September 1991 | pmid = 1898071 | doi = 10.1016/0003-9861(91)90471-T }}</ref><ref>{{cite journal | vauthors = Lewinsohn E, Gijzen M, Croteau R | title = Wound-inducible pinene cyclase from grand fir: purification, characterization, and renaturation after SDS-PAGE |author journal = Lewinsohn,Archives E.,of Gijzen, M.Biochemistry and Croteau, R.Biophysics |journal volume = Arch.293 Biochem.| Biophys. |yearissue = 19921 |volume pages = 293167–73 |pages date = 167–173February 1992 | pmid = 1731633 |issue=1 |doi = 10.1016/0003-9861(92)90380-f }}</ref><ref>{{cite journal | vauthors = Bohlmann J, Steele CL, Croteau R | title = Monoterpene synthases from grand fir (''Abies grandis''). cDNA isolation, characterization, and functional expression of myrcene synthase, (-–)-(4''S'')-limonene synthase, and (-–)-(1''S'',5''S'')-pinene synthase |author journal = Bohlmann,The J.,Journal Steele,of C.L.Biological andChemistry Croteau,| R. |journalvolume = J.272 Biol.| Chem. |yearissue = 199735 |volume pages = 27221784–92 |pages date = 21784–21792August 1997 | pmid = 9268308 | doi = 10.1074/jbc.272.35.21784 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Hyatt DC, Croteau R | title = Mutational analysis of a monoterpene synthase reaction: altered catalysis through directed mutagenesis of (-)-pinene synthase from ''Abies grandis'' |author journal = Hyatt,Archives D.C.of Biochemistry and Croteau,Biophysics R.| |journalvolume = Arch.439 Biochem.| Biophys. |yearissue = 20052 |volume pages = 439222–33 |pages date = 222–233July 2005 | pmid = 15978541 | doi = 10.1016/j.abb.2005.05.017 |issue=2}}</ref><ref>{{cite journal | vauthors = Savage TJ, Ichii H, Hume SD, Little DB, Croteau R | title = Monoterpene synthases from gymnosperms and angiosperms: stereospecificity and inactivation by cysteinyl- and arginyl-directed modifying reagents |author journal = Savage,Archives T.J.,of Ichii, H., Hume, S.D., Little, D.B.Biochemistry and Croteau, R.Biophysics |journal volume = Arch.320 Biochem.| Biophys. |yearissue = 19952 |volume pages = 320257–65 |pages date = 257–265July 1995 | pmid = 7625832 |issue=2 |doi = 10.1016/0003-9861(95)90008-x }}</ref><ref>{{cite journal | vauthors = Phillips MA, Savage TJ, Croteau R | title = Monoterpene synthases of loblolly pine (''Pinus taeda'') produce pinene isomers and enantiomers |author journal = Phillips,Archives M.A.,of Savage, T.J.Biochemistry and Croteau, R.Biophysics |journal volume = Arch.372 Biochem.| Biophys. |yearissue = 19991 |volume pages = 372197–204 |pages date = 197–204December 1999 | pmid = 10562434 | doi = 10.1006/abbi.1999.1467 |issue=1}}</ref><ref>{{cite journal | vauthors = McKay SA, Hunter WL, Godard KA, Wang SX, Martin DM, Bohlmann J, Plant AL | title = Insect attack and wounding induce traumatic resin duct development and gene expression of (-)-pinene synthase in Sitka spruce |author journal = McKay,Plant S.A.,Physiology Hunter,| W.L.,volume Godard,= K.A.,133 Wang,| S.X.,issue Martin,= D.M.,1 Bohlmann,| J.pages and= Plant, A.L.368–78 |journal date = PlantSeptember Physiol.2003 |year pmid = 200312970502 |volume = 133 |pagespmc = 368–378196613 |pmid =doi 12970502 |issue=1 |doi=10.1104/pp.103.022723 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[geranyl diphosphate]] <math>\rightleftharpoons</math> (-−)-[[betaβ-pinene]] + [[diphosphate]]

Cyclase II of ''[[Salvia officinalis]]'' (sage) produces about equal parts (-−)-[[alphaα-pinene]], (-−)-betaβ-pinene and (-−)-[[camphene]].

* {{MeshName|(-−)-beta-pinene+synthase}}

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