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{{Short description|American microbiologist}}
{{For|people with similar names|Daniel Nathan (disambiguation){{!}}Daniel Nathan}}
{{Infobox scientist
{{Infobox scientist
| name = Daniel Nathans
| name = Daniel Nathans
| image = Daniel_Nathans.jpg
| image = File:37. Tagung 1987 Mediziner Daniel Nathans lächelnd - W134Nr.125411c - Willy Pragher (cropped).jpg
| birth_date = {{Birth date|1928|10|30|mf=y}}
| birth_date = {{Birth date|1928|10|30|mf=y}}
| birth_place = [[Wilmington, Delaware|Wilmington]], [[Delaware]]
| birth_place = [[Wilmington, Delaware|Wilmington]], [[Delaware]]
Line 11: Line 13:
| ethnicity =
| ethnicity =
| field = [[Microbiology]]
| field = [[Microbiology]]
| work_institution = [[Johns Hopkins University]]
| work_institution = [[Johns Hopkins School of Medicine]]<br />[[Columbia Presbyterian Medical Center]]
| education = [[University of Delaware]] {{small|([[Bachelor of Science|BS]])}}<br />[[Washington University in St. Louis]] {{small|([[Doctor of Medicine|MD]])}}
| education = [[University of Delaware]] {{small|([[Bachelor of Science|BS]])}}<br />[[Washington University in St. Louis]] {{small|([[Doctor of Medicine|MD]])}}
| doctoral_advisor =
| doctoral_advisor =
| doctoral_students =
| doctoral_students = [[Robert Margolskee|Robert F. Margolskee]]<br />[[Marilyn Kozak|Marilyn S. Kozak]]
| known_for = [[Restriction enzymes]]
| known_for = [[Restriction enzymes]]
| prizes = {{no wrap|[[NAS Award in Molecular Biology]] {{small|(1976)}}<br>[[Nobel Prize in Physiology or Medicine]] {{small|(1978)}}<br>[[National Medal of Science]] {{small|(1993)}}}}
| prizes = {{no wrap|[[NAS Award in Molecular Biology]] {{small|(1976)}}<br>[[Nobel Prize in Physiology or Medicine]] {{small|(1978)}}<br>[[National Medal of Science]] {{small|(1993)}}}}
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|spouse =Joanne Gomberg
|spouse =Joanne Gomberg
}}
}}
'''Daniel Nathans''' (October 30, 1928 – November 16, 1999) was an American [[microbiologist]]. He shared the 1978 [[Nobel Prize in Physiology or Medicine]] for the discovery of [[restriction enzymes]].
'''Daniel Nathans''' (October 30, 1928 – November 16, 1999) was an American [[microbiologist]]. He shared the 1978 [[Nobel Prize in Physiology or Medicine]] for the discovery of [[restriction enzymes]] and their application in [[restriction mapping]].<ref>{{Nobelprize|accessdate=2020-10-11}}</ref>


==Early Life and Education==
==Early life and education==
Nathans was born in [[Wilmington, Delaware|Wilmington]], [[Delaware]], the last of nine children born to Russian Jewish immigrant parents, Sarah (Levitan) and Samuel Nathans. During the [[Great Depression]] his father lost his small business and was unemployed for a long period of time.
Nathans was born in [[Wilmington, Delaware|Wilmington]], [[Delaware]], the last of nine children born to Russian [[Jews|Jewish]] immigrant parents, Sarah (Levitan) and Samuel Nathans. During the [[Great Depression]] his father lost his small business and was unemployed for a long time.<ref name=":0">{{Cite web |date=2019-03-12 |title=Biographical Overview |url=https://profiles.nlm.nih.gov/spotlight/pd/feature/biographical-overview |access-date=2023-03-26 |website=Daniel Nathans - Profiles in Science |language=en}}</ref>


Nathans went to public schools and then to the [[University of Delaware]], where he received his [[Bachelor of Science|BS]] degree in chemistry in 1950. He received his [[Doctor of Medicine|MD]] degree from [[Washington University in St. Louis]] in 1954. After earning his MD degree, Nathans went to the [[Columbia-Presbyterian Medical Center]] for a one-year medical internship with Robert Loeb.
Nathans attended public schools and then to the [[University of Delaware]], where he received his [[Bachelor of Science|BS]] degree in chemistry in 1950. He received his [[Doctor of Medicine|MD]] degree from [[Washington University in St. Louis]] in 1954 and did a one-year internship at [[Presbyterian Medical Center]] with Robert Loeb.<ref name=":0" />


Wanting a break before his medical residency, Nathans became a clinical associate at the [[National Cancer Institute]] at the [[National Institutes of Health]] in Bethesda, Maryland. There he split his time between caring for patients receiving experimental cancer chemotherapy and research on recently discovered plasma-cell tumors in mice, similar to human multiple myeloma. Struck by how little was known about cancer biology, he became interested in protein synthesis in myeloma tumors, and published his first papers on this research.
Wanting a break before his medical residency, Nathans became a clinical associate at the [[National Cancer Institute]] at the [[National Institutes of Health]] in Bethesda, Maryland. There he split his time between caring for patients receiving experimental cancer chemotherapy and research on recently discovered plasma-cell tumors in mice, similar to human multiple myeloma. Struck by how little was known about cancer biology, he became interested in protein synthesis in myeloma tumors, and published his first papers on this research.<ref name=":0" />


Nathans returned to Columbia Presbyterian for a two-year residency in 1957, again on Robert Loeb's service. He continued working on the problem of protein synthesis as time allowed. In 1959, he decided to work on the research full time and became a research associate at Fritz Lipmann's lab at the [[Rockefeller University|Rockefeller Institute]] in New York.
Nathans returned to [[Columbia Presbyterian Medical Center]] for a two-year residency in 1957, again on Robert Loeb's service. He continued working on the problem of protein synthesis as time allowed. In 1959, he decided to work on the research full time and became a research associate at Fritz Lipmann's lab at the [[Rockefeller University|Rockefeller Institute]] in New York.<ref name=":0" />


==Career==
==Career==


In 1962, Nathans came to [[Johns Hopkins University School of Medicine]] as an assistant professor of microbiology. He was promoted to associate professor in 1965 and to professor in 1967. He became the director of the microbiology department in 1972 and served in that position until 1982. In 1981, the department of microbiology was renamed the department of molecular biology and genetics.
In 1962, Nathans came to [[Johns Hopkins School of Medicine]] as an assistant professor of microbiology. He was promoted to associate professor in 1965 and to professor in 1967. He became the director of the microbiology department in 1972 and served in that position until 1982. In 1981, the department of microbiology was renamed the department of molecular biology and genetics.


In 1982 [[Johns Hopkins University]] made Nathans a University Professor, a position in which he served until his death in 1999. He also became a senior investigator of the [[Howard Hughes Medical Institute]] unit at the School of Medicine in 1982.
In 1982 [[Johns Hopkins University]] made Nathans a University Professor, a position in which he served until his death in 1999. He also became a senior investigator of the [[Howard Hughes Medical Institute]] unit at [[Johns Hopkins School of Medicine]] in 1982.<ref>{{Cite web |title=The Nobel Prize in Physiology or Medicine 1978 |url=https://www.nobelprize.org/prizes/medicine/1978/nathans/facts/ |access-date=2023-03-26 |website=NobelPrize.org |language=en-US}}</ref>


From 1995-1996 Nathans served as the interim president of Johns Hopkins University.
From 1995 to 1996, Nathans served as the interim president of [[Johns Hopkins University]].


In January 1999, Johns Hopkins University established the McKusick-Nathans Institute of Genetic Medicine, a multidisciplinary clinical and research center named for Nathans and pioneering medical geneticist [[Victor McKusick]]. <ref>{{cite web|url=https://profiles.nlm.nih.gov/ps/retrieve/Narrative/PD/p-nid/317|title=The Daniel Nathans Papers: Biographical Information|author=|date=|website=profiles.nlm.nih.gov|accessdate=4 April 2018}}</ref> Nathans was also given six honorary doctorates over the span of his career.
In January 1999, [[Johns Hopkins School of Medicine]] established the McKusick-Nathans Institute of Genetic Medicine, a multidisciplinary clinical and research center named for Nathans and pioneering medical geneticist [[Victor McKusick]].<ref>{{cite web|url=https://profiles.nlm.nih.gov/ps/retrieve/Narrative/PD/p-nid/317|title=The Daniel Nathans Papers: Biographical Information|website=profiles.nlm.nih.gov|access-date=4 April 2018}}</ref>
Nathans was also given six honorary doctorates over the span of his career.


==Awards==
==Awards==
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* 1967: Selman Waksman Award in Microbiology
* 1967: Selman Waksman Award in Microbiology
* 1976: [[National Academy of Sciences|NAS]] Award in Molecular Biology
* 1976: [[National Academy of Sciences|NAS]] Award in Molecular Biology
* 1977: Elected to the [[American Academy of Arts and Sciences]]<ref>{{Cite web |title=Daniel Nathans |url=https://www.amacad.org/person/daniel-nathans |access-date=2022-05-16 |website=American Academy of Arts & Sciences |language=en}}</ref>
* 1978: [[Nobel Prize in Physiology or Medicine]]
* 1978: [[Nobel Prize in Physiology or Medicine]]
* 1979: Elected to the [[National Academy of Sciences]]
* 1979: Elected to the [[National Academy of Sciences]]<ref>{{Cite web |title=Daniel Nathans |url=http://www.nasonline.org/member-directory/deceased-members/52202.html |access-date=2022-05-16 |website=www.nasonline.org}}</ref>
* 1985: Elected to the [[American Philosophical Society]]<ref>{{Cite web |title=APS Member History |url=https://search.amphilsoc.org/memhist/search?creator=Daniel+Nathans&title=&subject=&subdiv=&mem=&year=&year-max=&dead=&keyword=&smode=advanced |access-date=2022-05-16 |website=search.amphilsoc.org}}</ref>
* 1993: [[National Medal of Science]]
* 1993: [[National Medal of Science]]


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*{{cite journal
*{{cite journal
|last=Brownlee
|last1=Brownlee
|first=Christen
|first1=Christen
|authorlink=
|date=April 2005
|date=April 2005
|title=Danna and Nathans: Restriction enzymes and the boon to modern molecular biology
|title=Danna and Nathans: Restriction enzymes and the boon to modern molecular biology
Line 68: Line 73:
|issue=17
|issue=17
|pages=5909
|pages=5909
| publisher = | location =
|doi = 10.1073/pnas.0502760102
|doi = 10.1073/pnas.0502760102
| bibcode =2005PNAS..102.5909B
| bibcode = | oclc =| id = | language = | format = | laysummary = | laysource = | laydate = | quote =
|last2=Nathans
|last2=Nathans
|first2=D | pmid=15840710 | pmc=1087965
|first2=D | pmid=15840710 | pmc=1087965
|doi-access=free
}}
}}
*{{cite journal
*{{cite journal
|last=Dimaio
|last=Dimaio
|first=D
|first=D
|authorlink=
|year=2001
|year=2001
|title=Daniel Nathans: October 30, 1928-November 16, 1999
|title=Daniel Nathans: October 30, 1928-November 16, 1999
|journal=[[Biographical memoirs. National Academy of Sciences (U.S.)]]
|journal=[[Biographical Memoirs of the National Academy of Sciences]]
|volume=79
|volume=79
|issue=
|pages=262–79
|pages=262–79
| publisher = | location =
| pmid = 11762397
| pmid = 11762397
| bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
}}
}}
*{{cite journal
*{{cite journal
|last=Raju
|last=Raju
|first=T N
|first=T N
|authorlink=
|date=October 1999
|date=October 1999
|title=The Nobel chronicles. 1978: Werner Arber (b 1929); Hamilton O Smith (b 1931); Daniel Nathans (b 1928)
|title=The Nobel chronicles. 1978: Werner Arber (b 1929); Hamilton O Smith (b 1931); Daniel Nathans (b 1928)
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|issue=9189
|issue=9189
|pages=1567
|pages=1567
| publisher = | location =
| pmid = 10551539
| pmid = 10551539
| bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
| doi = 10.1016/S0140-6736(05)76606-X
| doi = 10.1016/S0140-6736(05)76606-X
|s2cid=53257399
}}
}}
*{{cite journal
*{{cite journal
|last=Shampo
|last=Shampo
|first=M A
|first=M A
|authorlink=
|author2=Kyle R A
|author2=Kyle R A
|date=April 1996
|date=April 1996
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|issue=4
|issue=4
|pages=360
|pages=360
| publisher = | location =
| pmid = 8637258
| pmid = 8637258
| doi=10.4065/71.4.360
| bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi=10.4065/71.4.360
}}
}}
*{{cite journal
*{{cite journal
|last=Kroon
|last=Kroon
|first=A M
|first=A M
|authorlink=
|date=February 1979
|date=February 1979
|title=[The Nobel Prize for Medicine and Physiology in 1978 (Werner Arber, Daniel Nathans, Hamilton Smith)]
|title=The Nobel Prize for Medicine and Physiology in 1978 (Werner Arber, Daniel Nathans, Hamilton Smith)
|journal=[[Nederlands tijdschrift voor geneeskunde]]
|journal=[[Nederlands Tijdschrift voor Geneeskunde]]
|volume=123
|volume=123
|issue=5
|issue=5
|pages=153–6
|pages=153–6
| publisher = | location =
| pmid = 368662
| pmid = 368662
| bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
}}
}}
*{{cite journal
*{{cite journal
|last=Piekarowicz
|last=Piekarowicz
|first=A
|first=A
|authorlink=
|year=1979
|year=1979
|title=[Werner Arber, Daniel Nathans and Hamilton Smith. Nobel prizes for the studies on DNA restriction enzymes]
|title=[Werner Arber, Daniel Nathans and Hamilton Smith. Nobel prizes for the studies on DNA restriction enzymes]
Line 142: Line 135:
|issue=2
|issue=2
|pages=251–3
|pages=251–3
| publisher = | location =
| pmid = 388391
| pmid = 388391
| bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
}}
}}
*{{cite journal
*{{cite journal
|last=Desiderio
|last=Desiderio
|first=S
|first=S
|authorlink=
|author2=Boyer S
|author2=Boyer S
|date=November 1978
|date=November 1978
Line 157: Line 147:
|issue=5
|issue=5
|pages=ix–x
|pages=ix–x
| publisher = | location =
| pmid = 364154
| pmid = 364154
| bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote =
}}
}}


==External links==
==External links==
*{{Nobelprize}}
*[http://nobelprize.org/medicine/laureates/1978/nathans-autobio.html Nobel Autobiography]
*[https://profiles.nlm.nih.gov/PD/ The Daniel Nathans Papers] - Profiles in Science, National Library of Medicine
*[https://profiles.nlm.nih.gov/PD/ The Daniel Nathans Papers] - Profiles in Science, National Library of Medicine
* {{Biographical Memoirs|nathans-daniel}}
* {{Biographical Memoirs|nathans-daniel}}
{{Johns Hopkins presidents}}
{{Johns Hopkins presidents}}
{{Nobel Prize in Physiology or Medicine Laureates 1976-2000}}
{{Nobel Prize in Physiology or Medicine Laureates 1976-2000}}
{{1978 Nobel Prize winners}}
{{Winners of the National Medal of Science|biological}}
{{Winners of the National Medal of Science|biological}}


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[[Category:1928 births]]
[[Category:1928 births]]
[[Category:1999 deaths]]
[[Category:1999 deaths]]
[[Category:Nobel laureates in Physiology or Medicine]]
[[Category:American Nobel laureates]]
[[Category:Nobel laureates affiliated with Missouri]]
[[Category:American microbiologists]]
[[Category:American microbiologists]]
[[Category:Jewish biologists]]
[[Category:Jewish American scientists]]
[[Category:Jewish American scientists]]
[[Category:Johns Hopkins University faculty]]
[[Category:Johns Hopkins University faculty]]
[[Category:National Medal of Science laureates]]
[[Category:National Medal of Science laureates]]
[[Category:Nobel laureates in Physiology or Medicine]]
[[Category:Columbia University people]]
[[Category:American Nobel laureates]]
[[Category:Scientists from Wilmington, Delaware]]
[[Category:People from Wilmington, Delaware]]
[[Category:Presidents of Johns Hopkins University]]
[[Category:Presidents of Johns Hopkins University]]
[[Category:Washington University in St. Louis alumni]]
[[Category:Washington University School of Medicine alumni]]
[[Category:American people of Russian-Jewish descent]]
[[Category:American people of Russian-Jewish descent]]
[[Category:University of Delaware alumni]]
[[Category:University of Delaware alumni]]
[[Category:Howard Hughes Medical Investigators]]
[[Category:Howard Hughes Medical Investigators]]
[[Category:Members of the United States National Academy of Sciences]]
[[Category:Members of the American Philosophical Society]]
[[Category:Washington University in St. Louis alumni]]
[[Category:Cornell University people]]

Latest revision as of 09:23, 28 January 2024

For people with similar names, see Daniel Nathan.
Daniel Nathans
Born(1928-10-30)October 30, 1928
Wilmington, Delaware
DiedNovember 16, 1999(1999-11-16) (aged 71)
Baltimore, Maryland
NationalityAmerican
EducationUniversity of Delaware (BS)
Washington University in St. Louis (MD)
Known forRestriction enzymes
SpouseJoanne Gomberg
AwardsNAS Award in Molecular Biology (1976)
Nobel Prize in Physiology or Medicine (1978)
National Medal of Science (1993)
Scientific career
FieldsMicrobiology
InstitutionsJohns Hopkins School of Medicine
Columbia Presbyterian Medical Center
Doctoral studentsRobert F. Margolskee
Marilyn S. Kozak

Daniel Nathans (October 30, 1928 – November 16, 1999) was an American microbiologist. He shared the 1978 Nobel Prize in Physiology or Medicine for the discovery of restriction enzymes and their application in restriction mapping.[1]

Early life and education

[edit]

Nathans was born in Wilmington, Delaware, the last of nine children born to Russian Jewish immigrant parents, Sarah (Levitan) and Samuel Nathans. During the Great Depression his father lost his small business and was unemployed for a long time.[2]

Nathans attended public schools and then to the University of Delaware, where he received his BS degree in chemistry in 1950. He received his MD degree from Washington University in St. Louis in 1954 and did a one-year internship at Presbyterian Medical Center with Robert Loeb.[2]

Wanting a break before his medical residency, Nathans became a clinical associate at the National Cancer Institute at the National Institutes of Health in Bethesda, Maryland. There he split his time between caring for patients receiving experimental cancer chemotherapy and research on recently discovered plasma-cell tumors in mice, similar to human multiple myeloma. Struck by how little was known about cancer biology, he became interested in protein synthesis in myeloma tumors, and published his first papers on this research.[2]

Nathans returned to Columbia Presbyterian Medical Center for a two-year residency in 1957, again on Robert Loeb's service. He continued working on the problem of protein synthesis as time allowed. In 1959, he decided to work on the research full time and became a research associate at Fritz Lipmann's lab at the Rockefeller Institute in New York.[2]

Career

[edit]

In 1962, Nathans came to Johns Hopkins School of Medicine as an assistant professor of microbiology. He was promoted to associate professor in 1965 and to professor in 1967. He became the director of the microbiology department in 1972 and served in that position until 1982. In 1981, the department of microbiology was renamed the department of molecular biology and genetics.

In 1982 Johns Hopkins University made Nathans a University Professor, a position in which he served until his death in 1999. He also became a senior investigator of the Howard Hughes Medical Institute unit at Johns Hopkins School of Medicine in 1982.[3]

From 1995 to 1996, Nathans served as the interim president of Johns Hopkins University.

In January 1999, Johns Hopkins School of Medicine established the McKusick-Nathans Institute of Genetic Medicine, a multidisciplinary clinical and research center named for Nathans and pioneering medical geneticist Victor McKusick.[4]

Nathans was also given six honorary doctorates over the span of his career.

Awards

[edit]

See also

[edit]

References

[edit]
  1. ^ Daniel Nathans on Nobelprize.org Edit this at Wikidata, accessed 11 October 2020
  2. ^ a b c d "Biographical Overview". Daniel Nathans - Profiles in Science. 2019-03-12. Retrieved 2023-03-26.
  3. ^ "The Nobel Prize in Physiology or Medicine 1978". NobelPrize.org. Retrieved 2023-03-26.
  4. ^ "The Daniel Nathans Papers: Biographical Information". profiles.nlm.nih.gov. Retrieved 4 April 2018.
  5. ^ "Daniel Nathans". American Academy of Arts & Sciences. Retrieved 2022-05-16.
  6. ^ "Daniel Nathans". www.nasonline.org. Retrieved 2022-05-16.
  7. ^ "APS Member History". search.amphilsoc.org. Retrieved 2022-05-16.

Further reading

[edit]
[edit]
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