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vesicular-tubular cluster:

An intermediate compartment mediating trafficking between the endoplasmic reticulum and Golgi complex. COPII vesicles that have budded from exit sites in the endoplasmic reticulum lose their coats and fuse to form the vesicular-tubular cluster (VTC). Retrieval (or retrograde) transport in COPI vesicles returns many of the lost ER resident proteins back to the endoplasmic reticulum. Forward (or anterograde) transport moves the VTC contents to the cis-Golgi network, the receiving face of the Golgi complex. This process is thought to occur by one of two process. One process is is known as cisternal maturation where the VTC simply matures into the cis-Golgi network. In another COPI vesicular transport moves VTC material to the recieving face of the Golgi apparatus. A fuller explanation of the two processes is described (see Golgi complex). Evidence exists for both processes and it may be that both occur simultaneously in cells.

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	'''vesicular-tubular cluster''':		'''vesicular-tubular cluster''':

	An intermediate compartment mediating trafficking between the [[endoplasmic reticulum]] and [[Golgi complex]]. [[COPII]] vesicles that have budded from exit sites in the endoplasmic reticulum lose their coats and fuse to form the vesicular-tubular cluster (VTC). Retrieval (or retrograde) transport in [[COPI]] vesicles returns many of the lost ER resident proteins back to the endoplasmic reticulum. Forward (or anterograde) transport moves the VTC contents to the [[cis-Golgi network]], the receiving face of the Golgi complex. This process is thought to occur by one of two process. One process is is known as cisternal maturation where the VTC simply matures into the cis-Golgi network. In another COPI vesicular transport moves VTC material to the recieving face of the Golgi apparatus. A fuller explanation of the two processes is described (see [[Golgi complex]]). Evidence exists for both processes and it may be that both occur simultaneously in cells.		An intermediate compartment mediating trafficking between the [[endoplasmic reticulum]] and [[Golgi complex]]. [[COPII]] vesicles that have budded from exit sites in the endoplasmic reticulum lose their coats and fuse to form the vesicular-tubular cluster (VTC). Retrieval (or retrograde) transport in [[COPI]] vesicles returns many of the lost ER resident proteins back to the endoplasmic reticulum. Forward (or anterograde) transport moves the VTC contents to the cis-Golgi network, the receiving face of the Golgi complex. This process is thought to occur by one of two process. One process is is known as cisternal maturation where the VTC simply matures into the cis-Golgi network. In another COPI vesicular transport moves VTC material to the recieving face of the Golgi apparatus. A fuller explanation of the two processes is described (see [[Golgi complex]]). Evidence exists for both processes and it may be that both occur simultaneously in cells.