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{{Short description|Family of transcription factors}}
{{protein
{{infobox protein
| Name = [[TFAP2A|transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)]]
| Name = [[TFAP2A|transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)]]
| image =
| image =
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}}
}}


{{protein
{{infobox protein
| Name = transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
| Name = transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
| image =
| image =
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}}
}}


{{protein
{{infobox protein
| Name = transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
| Name = transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
| image =
| image =
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}}
}}


{{protein
{{infobox protein
| Name = transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
| Name = transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
| image =
| image =
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}}
}}


{{protein
{{infobox protein
| Name = transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
| Name = transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
| image =
| image =
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}}
}}


'''Activating Protein 2''' ('''AP-2''') is a family of closely related [[transcription factor]]s<ref name="pmid1998122">{{cite journal |author=Williams T, Tjian R |title=Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins |journal=Science |volume=251 |issue=4997 |pages=1067-71 |year=1991 |pmid=1998122 |doi= 10.1126/science.1998122 |issn=}}</ref><ref name="pmid2010091">{{cite journal |author=Williams T, Tjian R |title=Analysis of the DNA-binding and activation properties of the human transcription factor AP-2 |journal=Genes Dev. |volume=5 |issue=4 |pages=670-82 |year=1991 |pmid=2010091 |doi= 10.1101/gad.5.4.670 |issn=}}</ref> which plays a critical role in regulating gene expression during early development.<ref name="pmid11137286">{{cite journal |author=Hilger-Eversheim K, Moser M, Schorle H, Buettner R |title=Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control |journal=Gene |volume=260 |issue=1-2 |pages=1-12 |year=2000 |pmid=11137286 |doi= 10.1016/S0378-1119(00)00454-6 |issn=}}</ref>
'''Activating Protein 2''' ('''AP-2''') is a family of closely related [[transcription factor]]s<ref name="pmid1998122">{{cite journal |vauthors =Williams T, Tjian R |title=Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins |journal=Science |volume=251 |issue=4997 |pages=1067–71 |year=1991 |pmid=1998122 |doi= 10.1126/science.1998122|bibcode=1991Sci...251.1067W }}</ref><ref name="pmid2010091">{{cite journal |vauthors =Williams T, Tjian R |title=Analysis of the DNA-binding and activation properties of the human transcription factor AP-2 |journal=Genes Dev. |volume=5 |issue=4 |pages=670–82 |year=1991 |pmid=2010091 |doi= 10.1101/gad.5.4.670|doi-access=free }}</ref> which plays a critical role in regulating gene expression during early development.<ref name="pmid11137286">{{cite journal |vauthors =Hilger-Eversheim K, Moser M, Schorle H, Buettner R |title=Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control |journal=Gene |volume=260 |issue=1–2 |pages=1–12 |year=2000 |pmid=11137286 |doi= 10.1016/S0378-1119(00)00454-6}}</ref>


==References==
==References==
{{Reflist}}
<div class="references-small"><references /></div>


==External links==
==External links==
* {{MeshName|nuclear+receptor+corepressor+2}}
* {{MeshName|Transcription+Factor+AP-2}}


⚫
{{Transcription factors|g1}}
⚫
{{biochem-stub}}
{{Transcription coregulators}}


{{Cell_signaling}}
⚫
{{Transcription factors}}
[[Category:Gene expression]]
[[Category:Gene expression]]
[[Category:Transcription factors]]
[[Category:Transcription factors]]


⚫
{{gene-20-stub}}

Latest revision as of 01:17, 8 March 2022

transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Identifiers
SymbolTFAP2A
Alt. symbolsTFAP2, AP2TF
NCBI gene7020
HGNC11742
OMIM107580
RefSeqNM_003220
UniProtP05549
Other data
LocusChr. 6 p22.3
Search for
StructuresSwiss-model
DomainsInterPro
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Identifiers
SymbolTFAP2B
Alt. symbolsAP2-B
NCBI gene7021
HGNC11743
OMIM601601
RefSeqNM_003221
UniProtQ92481
Other data
LocusChr. 6 p12
Search for
StructuresSwiss-model
DomainsInterPro
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
Identifiers
SymbolTFAP2C
NCBI gene7022
HGNC11744
OMIM601602
RefSeqNM_003222
UniProtQ92754
Other data
LocusChr. 20 q13.2
Search for
StructuresSwiss-model
DomainsInterPro
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
Identifiers
SymbolTFAP2D
Alt. symbolsTFAP2BL1
NCBI gene83741
HGNC15581
OMIM610161
RefSeqNM_172238
UniProtQ7Z6R9
Other data
LocusChr. 6 p12.3
Search for
StructuresSwiss-model
DomainsInterPro
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
Identifiers
SymbolTFAP2E
Alt. symbolsAP2E
NCBI gene339488
HGNC30774
RefSeqNM_178548
UniProtQ6VUC0
Other data
LocusChr. 1 p34.3
Search for
StructuresSwiss-model
DomainsInterPro

Activating Protein 2 (AP-2) is a family of closely related transcription factors[1][2] which plays a critical role in regulating gene expression during early development.[3]

References

[edit]
  1. ^ Williams T, Tjian R (1991). "Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins". Science. 251 (4997): 1067–71. Bibcode:1991Sci...251.1067W. doi:10.1126/science.1998122. PMID 1998122.
  2. ^ Williams T, Tjian R (1991). "Analysis of the DNA-binding and activation properties of the human transcription factor AP-2". Genes Dev. 5 (4): 670–82. doi:10.1101/gad.5.4.670. PMID 2010091.
  3. ^ Hilger-Eversheim K, Moser M, Schorle H, Buettner R (2000). "Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control". Gene. 260 (1–2): 1–12. doi:10.1016/S0378-1119(00)00454-6. PMID 11137286.
[edit]


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