GPR37: Difference between revisions

GPR37
Identifiers
Aliases	GPR37, EDNRBL, PAELR, hET(B)R-LP, G protein-coupled receptor 37
External IDs	OMIM: 602583; MGI: 1313297; HomoloGene: 3875; GeneCards: GPR37; OMA:GPR37 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	124,765,792 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	25,690,728 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; inferior ganglion of vagus nerve; ; optic nerve; ; middle frontal gyrus; ; subthalamic nucleus; ; medulla oblongata; ; ventral tegmental area; ; superior vestibular nucleus; ; external globus pallidus; ; inferior olivary nucleus;
	Top expressed in
	deep cerebellar nuclei; ; lumbar subsegment of spinal cord; ; globus pallidus; ; lateral geniculate nucleus; ; utricle; ; vestibular sensory epithelium; ; pontine nuclei; ; medial geniculate nucleus; ; anterior horn of spinal cord; ; ventral tegmental area;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled peptide receptor activity; G protein-coupled receptor activity; heat shock protein binding; prosaposin receptor activity; peptide binding; signal transducer activity; Hsp70 protein binding; protein binding; ubiquitin protein ligase binding;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; ubiquitin ligase complex; receptor complex; plasma membrane; integral component of plasma membrane; endoplasmic reticulum;
Biological process	G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; dopamine biosynthetic process; negative regulation of hydrogen peroxide-induced cell death; locomotion involved in locomotory behavior; positive regulation of MAPK cascade; signal transduction; positive regulation of dopamine metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2861
	14763
	ENSG00000170775
	ENSMUSG00000039904
	O15354
	Q9QY42
	NM_005302
	NM_010338
	NP_005293
	NP_034468
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 01:36, 7 November 2019

Probable G-protein coupled receptor 37 is a protein that in humans is encoded by the GPR37 gene.^[5]^[6]

Interactions

GPR37 has been shown to interact with HSPA1A^[7] and Parkin (ligase).^[7]^[8] GPR37 is a receptor for prosaposin. It was previously thought to be a receptor for head activator, a neuropeptide found in the hydra, but early reports of head activator in mammals were never confirmed.^[9]

GPR37 signaling has been shown to modulate the migration of olfactory ensheathing cells (OECs) and gonadotropin-releasing hormone (GnRH) cells in mice.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170775 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039904 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (November 1997). "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library". Genomics. 45 (1): 68–77. doi:10.1006/geno.1997.4900. PMID 9339362.
^ "Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)".
^ ^a ^b Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (July 2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Molecular Cell. 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. PMID 12150907.
^ Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (June 2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin". Cell. 105 (7): 891–902. doi:10.1016/S0092-8674(01)00407-X. PMID 11439185.
^ Meyer, Rebecca C.; Giddens, Michelle M.; Schaefer, Stacy A.; Hall, Randy A. (4 June 2013). "GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin". Proceedings of the National Academy of Sciences. 110 (23): 9529–34. Bibcode:2013PNAS..110.9529M. doi:10.1073/pnas.1219004110. PMC 3677493. PMID 23690594.
^ Saadi H, Shan Y, Wray S (2019). "GPR37 Signaling Modulates Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Cells in Mice". Frontiers in Cellular Neuroscience. 13: 200. doi:10.3389/fncel.2019.00200. PMC 6521704. PMID 31143101.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Zeng Z, Su K, Kyaw H, Li Y (1997). "A novel endothelin receptor type-B-like gene enriched in the brain". Biochemical and Biophysical Research Communications. 233 (2): 559–67. doi:10.1006/bbrc.1997.6408. PMID 9144577.
Donohue PJ, Shapira H, Mantey SA, Hampton LL, Jensen RT, Battey JF (1998). "A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system". Molecular Brain Research. 54 (1): 152–60. doi:10.1016/S0169-328X(97)00336-7. PMID 9526070.
Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin". Cell. 105 (7): 891–902. doi:10.1016/S0092-8674(01)00407-X. PMID 11439185.
Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Molecular Cell. 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. PMID 12150907.
Yang Y, Nishimura I, Imai Y, Takahashi R, Lu B (2003). "Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila". Neuron. 37 (6): 911–24. doi:10.1016/S0896-6273(03)00143-0. PMID 12670421.
Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (2003). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". Journal of Biological Chemistry. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Kubota K, Niinuma Y, Kaneko M, Okuma Y, Sugai M, Omura T, Uesugi M, Uehara T, Hosoi T, Nomura Y (2006). "Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress". Journal of Neurochemistry. 97 (5): 1259–68. doi:10.1111/j.1471-4159.2006.03782.x. PMID 16539653.
Omura T, Kaneko M, Okuma Y, Orba Y, Nagashima K, Takahashi R, Fujitani N, Matsumura S, Hata A, Kubota K, Murahashi K, Uehara T, Nomura Y (2006). "A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin" (PDF). Journal of Neurochemistry. 99 (6): 1456–69. doi:10.1111/j.1471-4159.2006.04155.x. hdl:2115/17141. PMID 17059562.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170775 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039904 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9339362-5] Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (November 1997). "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library". Genomics. 45 (1): 68–77. doi:10.1006/geno.1997.4900. PMID 9339362.

[entrez-6] "Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)".

[pmid12150907-7] Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (July 2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Molecular Cell. 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. PMID 12150907.

[pmid11439185-8] Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (June 2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin". Cell. 105 (7): 891–902. doi:10.1016/S0092-8674(01)00407-X. PMID 11439185.

[9] Meyer, Rebecca C.; Giddens, Michelle M.; Schaefer, Stacy A.; Hall, Randy A. (4 June 2013). "GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin". Proceedings of the National Academy of Sciences. 110 (23): 9529–34. Bibcode:2013PNAS..110.9529M. doi:10.1073/pnas.1219004110. PMC 3677493. PMID 23690594.

[10] Saadi H, Shan Y, Wray S (2019). "GPR37 Signaling Modulates Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Cells in Mice". Frontiers in Cellular Neuroscience. 13: 200. doi:10.3389/fncel.2019.00200. PMC 6521704. PMID 31143101.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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@@ Line 4: / Line 4: @@
 == Interactions ==
-GPR37 has been shown to [[Protein-protein interaction|interact]] with [[HSPA1A]]<ref name=pmid12150907>{{cite journal | vauthors = Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R | title = CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity | journal = Mol. Cell | volume = 10 | issue = 1 | pages = 55–67  | date = July 2002 | pmid = 12150907 | doi = 10.1016/S1097-2765(02)00583-X }}</ref> and [[Parkin (ligase)]].<ref name=pmid12150907/><ref name=pmid11439185>{{cite journal | vauthors = Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R | title = An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin | journal = Cell | volume = 105 | issue = 7 | pages = 891–902  | date = June 2001 | pmid = 11439185 | doi = 10.1016/S0092-8674(01)00407-X }}</ref>
+GPR37 has been shown to [[Protein-protein interaction|interact]] with [[HSPA1A]]<ref name=pmid12150907>{{cite journal | vauthors = Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R | title = CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity | journal =  Molecular Cell| volume = 10 | issue = 1 | pages = 55–67  | date = July 2002 | pmid = 12150907 | doi = 10.1016/S1097-2765(02)00583-X }}</ref> and [[Parkin (ligase)]].<ref name=pmid12150907/><ref name=pmid11439185>{{cite journal | vauthors = Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R | title = An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin | journal = Cell | volume = 105 | issue = 7 | pages = 891–902  | date = June 2001 | pmid = 11439185 | doi = 10.1016/S0092-8674(01)00407-X }}</ref>
-GPR37 is a receptor for [[prosaposin]]. It was previously thought to be a receptor for [[head activator]], a [[neuropeptide]] found in the [[hydra (genus)|hydra]], but early reports of head activator in mammals were never confirmed.<ref>{{cite journal |first1=Rebecca C.|last1=Meyer |first2=Michelle M.|last2=Giddens |first3=Stacy A.|last3=Schaefer |first4=Randy A.|last4=Hall |title=GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin |date=4 June 2013 |journal=Proceedings of the National Academy of Sciences |volume=110 |issue=23 |pages=9529–34 |doi=10.1073/pnas.1219004110 |pmid=23690594 |pmc=3677493}}
+GPR37 is a receptor for [[prosaposin]]. It was previously thought to be a receptor for [[head activator]], a [[neuropeptide]] found in the [[hydra (genus)|hydra]], but early reports of head activator in mammals were never confirmed.<ref>{{cite journal |first1=Rebecca C.|last1=Meyer |first2=Michelle M.|last2=Giddens |first3=Stacy A.|last3=Schaefer |first4=Randy A.|last4=Hall |title=GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin |date=4 June 2013 |journal=Proceedings of the National Academy of Sciences |volume=110 |issue=23 |pages=9529–34 |doi=10.1073/pnas.1219004110 |pmid=23690594 |pmc=3677493|bibcode=2013PNAS..110.9529M }}
 </ref>
-GPR37 signaling has been shown to modulate the migration of [[olfactory ensheathing cells]] (OECs) and [[gonadotropin-releasing hormone]] (GnRH) cells in mice.<ref>{{cite journal | vauthors = Saadi H, Shan Y, Wray S | title = GPR37 Signaling Modulates Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Cells in Mice | journal = Front Cell Neurosci. | pmid = 31143101 | doi = 10.3389/fncel.2019.00200 }}</ref>
+GPR37 signaling has been shown to modulate the migration of [[olfactory ensheathing cells]] (OECs) and [[gonadotropin-releasing hormone]] (GnRH) cells in mice.<ref>{{cite journal | vauthors = Saadi H, Shan Y, Wray S | title = GPR37 Signaling Modulates Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Cells in Mice | journal = Frontiers in Cellular Neuroscience| volume = 13 | pages = 200 | pmid = 31143101 | pmc = 6521704 | doi = 10.3389/fncel.2019.00200 | year = 2019 }}</ref>
 == References ==
@@ Line 15: / Line 15: @@
 == Further reading ==
 {{refbegin | 2}}
-* {{cite journal | vauthors = Zeng Z, Su K, Kyaw H, Li Y | title = A novel endothelin receptor type-B-like gene enriched in the brain | journal = Biochem. Biophys. Res. Commun. | volume = 233 | issue = 2 | pages = 559–67 | year = 1997 | pmid = 9144577 | doi = 10.1006/bbrc.1997.6408 }}
+* {{cite journal | vauthors = Zeng Z, Su K, Kyaw H, Li Y | title = A novel endothelin receptor type-B-like gene enriched in the brain | journal = Biochemical and Biophysical Research Communications| volume = 233 | issue = 2 | pages = 559–67 | year = 1997 | pmid = 9144577 | doi = 10.1006/bbrc.1997.6408 }}
-* {{cite journal | vauthors = Donohue PJ, Shapira H, Mantey SA, Hampton LL, Jensen RT, Battey JF | title = A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system | journal = Brain Res. Mol. Brain Res. | volume = 54 | issue = 1 | pages = 152–60 | year = 1998 | pmid = 9526070 | doi = 10.1016/S0169-328X(97)00336-7 | url = https://zenodo.org/record/1259931 }}
+* {{cite journal | vauthors = Donohue PJ, Shapira H, Mantey SA, Hampton LL, Jensen RT, Battey JF | title = A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system | journal = Molecular Brain Research| volume = 54 | issue = 1 | pages = 152–60 | year = 1998 | pmid = 9526070 | doi = 10.1016/S0169-328X(97)00336-7 | url = https://zenodo.org/record/1259931 }}
 * {{cite journal | vauthors = Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R | title = An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin | journal = Cell | volume = 105 | issue = 7 | pages = 891–902 | year = 2001 | pmid = 11439185 | doi = 10.1016/S0092-8674(01)00407-X }}
-* {{cite journal | vauthors = Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R | title = CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity | journal = Mol. Cell | volume = 10 | issue = 1 | pages = 55–67 | year = 2002 | pmid = 12150907 | doi = 10.1016/S1097-2765(02)00583-X }}
+* {{cite journal | vauthors = Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R | title = CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity | journal =  Molecular Cell| volume = 10 | issue = 1 | pages = 55–67 | year = 2002 | pmid = 12150907 | doi = 10.1016/S1097-2765(02)00583-X }}
 * {{cite journal | vauthors = Yang Y, Nishimura I, Imai Y, Takahashi R, Lu B | title = Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila | journal = Neuron | volume = 37 | issue = 6 | pages = 911–24 | year = 2003 | pmid = 12670421 | doi = 10.1016/S0896-6273(03)00143-0 }}
-* {{cite journal | vauthors = Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R | title = A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death | journal = J. Biol. Chem. | volume = 278 | issue = 51 | pages = 51901–10 | year = 2003 | pmid = 14532270 | doi = 10.1074/jbc.M309655200 }}
+* {{cite journal | vauthors = Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R | title = A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death | journal =   Journal of Biological Chemistry| volume = 278 | issue = 51 | pages = 51901–10 | year = 2003 | pmid = 14532270 | doi = 10.1074/jbc.M309655200 }}
-* {{cite journal | vauthors = Kubota K, Niinuma Y, Kaneko M, Okuma Y, Sugai M, Omura T, Uesugi M, Uehara T, Hosoi T, Nomura Y | title = Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress | journal = J. Neurochem. | volume = 97 | issue = 5 | pages = 1259–68 | year = 2006 | pmid = 16539653 | doi = 10.1111/j.1471-4159.2006.03782.x }}
+* {{cite journal | vauthors = Kubota K, Niinuma Y, Kaneko M, Okuma Y, Sugai M, Omura T, Uesugi M, Uehara T, Hosoi T, Nomura Y | title = Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress | journal =  Journal of Neurochemistry| volume = 97 | issue = 5 | pages = 1259–68 | year = 2006 | pmid = 16539653 | doi = 10.1111/j.1471-4159.2006.03782.x }}
-* {{cite journal | vauthors = Omura T, Kaneko M, Okuma Y, Orba Y, Nagashima K, Takahashi R, Fujitani N, Matsumura S, Hata A, Kubota K, Murahashi K, Uehara T, Nomura Y | title = A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin | journal = J. Neurochem. | volume = 99 | issue = 6 | pages = 1456–69 | year = 2006 | pmid = 17059562 | doi = 10.1111/j.1471-4159.2006.04155.x | url = http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/17141/1/JN99-6-2006.pdf | hdl = 2115/17141 }}
+* {{cite journal | vauthors = Omura T, Kaneko M, Okuma Y, Orba Y, Nagashima K, Takahashi R, Fujitani N, Matsumura S, Hata A, Kubota K, Murahashi K, Uehara T, Nomura Y | title = A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin | journal = Journal of Neurochemistry| volume = 99 | issue = 6 | pages = 1456–69 | year = 2006 | pmid = 17059562 | doi = 10.1111/j.1471-4159.2006.04155.x | url = http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/17141/1/JN99-6-2006.pdf | hdl = 2115/17141 }}
 {{refend}}