ID2: Difference between revisions

ID2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AYA
Identifiers
Aliases	ID2, GIG8, ID2A, ID2H, bHLHb26, inhibitor of DNA binding 2, HLH protein, inhibitor of DNA binding 2
External IDs	OMIM: 600386; MGI: 96397; HomoloGene: 1632; GeneCards: ID2; OMA:ID2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	8,684,461 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	25,147,139 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; saphenous vein; ; pericardium; ; right lobe of liver; ; granulocyte; ; trachea; ; lower lobe of lung; ; renal medulla; ; seminal vesicula;
	Top expressed in
	vas deferens; ; seminal vesicula; ; lobe of cerebellum; ; migratory enteric neural crest cell; ; cerebellar vermis; ; abdominal wall; ; dermis; ; left lung lobe; ; hand; ; parotid gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein dimerization activity; transmembrane transporter binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity; transcription factor binding;
Cellular component	nucleus; cytosol; cytoplasm; protein-containing complex;
Biological process	regulation of G1/S transition of mitotic cell cycle; rhythmic process; negative regulation of DNA-binding transcription factor activity; regulation of transcription, DNA-templated; positive regulation of transcription involved in G1/S transition of mitotic cell cycle; multicellular organism development; negative regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; metanephros development; natural killer cell differentiation; thigmotaxis; leukocyte differentiation; membranous septum morphogenesis; bundle of His development; heart development; circadian rhythm; adult locomotory behavior; entrainment of circadian clock; positive regulation of gene expression; negative regulation of gene expression; oligodendrocyte development; regulation of lipid metabolic process; olfactory bulb development; circadian regulation of gene expression; mammary gland epithelial cell proliferation; regulation of circadian rhythm; entrainment of circadian clock by photoperiod; enucleate erythrocyte differentiation; negative regulation of DNA binding; locomotor rhythm; negative regulation of B cell differentiation; positive regulation of fat cell differentiation; positive regulation of erythrocyte differentiation; positive regulation of macrophage differentiation; negative regulation of neuron differentiation; negative regulation of osteoblast differentiation; positive regulation of blood pressure; positive regulation of transcription, DNA-templated; cell development; cell maturation; Peyer's patch development; embryonic digestive tract morphogenesis; positive regulation of smooth muscle cell proliferation; neuron fate commitment; cell morphogenesis involved in neuron differentiation; positive regulation of astrocyte differentiation; negative regulation of oligodendrocyte differentiation; adipose tissue development; mammary gland alveolus development; epithelial cell differentiation involved in mammary gland alveolus development; endodermal digestive tract morphogenesis; cellular response to lithium ion; cellular senescence; negative regulation of neural precursor cell proliferation; neuron differentiation; regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	3398
	15902
	ENSG00000115738
	ENSMUSG00000020644
	Q02363
	P41136
	NM_002166
	NM_010496
	NP_002157
	NP_034626
	Wikidata
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Revision as of 20:23, 9 June 2008

Template:PBB Controls

Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, also known as ID2, is a human gene.

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115738 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020644 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

External links

ID2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115738 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020644 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Biggs J, Murphy EV, Israel MA |title=A human Id-like helix-loop-helix protein expressed during early development. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1512-6 |year= 1992 |pmid= 1741406 |doi=  }}
+*{{cite journal  | author=Biggs J, Murphy EV, Israel MA |title=A human Id-like helix-loop-helix protein expressed during early development. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1512–6 |year= 1992 |pmid= 1741406 |doi=  }}
-*{{cite journal  | author=Iavarone A, Garg P, Lasorella A, ''et al.'' |title=The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. |journal=Genes Dev. |volume=8 |issue= 11 |pages= 1270-84 |year= 1994 |pmid= 7926730 |doi=  }}
+*{{cite journal  | author=Iavarone A, Garg P, Lasorella A, ''et al.'' |title=The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. |journal=Genes Dev. |volume=8 |issue= 11 |pages= 1270–84 |year= 1994 |pmid= 7926730 |doi=  }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=  }}
-*{{cite journal  | author=Kurabayashi M, Jeyaseelan R, Kedes L |title=Two distinct cDNA sequences encoding the human helix-loop-helix protein Id2. |journal=Gene |volume=133 |issue= 2 |pages= 305-6 |year= 1993 |pmid= 8224921 |doi=  }}
+*{{cite journal  | author=Kurabayashi M, Jeyaseelan R, Kedes L |title=Two distinct cDNA sequences encoding the human helix-loop-helix protein Id2. |journal=Gene |volume=133 |issue= 2 |pages= 305–6 |year= 1993 |pmid= 8224921 |doi=  }}
-*{{cite journal  | author=Hara E, Yamaguchi T, Nojima H, ''et al.'' |title=Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 2139-45 |year= 1994 |pmid= 8294468 |doi=  }}
+*{{cite journal  | author=Hara E, Yamaguchi T, Nojima H, ''et al.'' |title=Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 2139–45 |year= 1994 |pmid= 8294468 |doi=  }}
-*{{cite journal  | author=Mathew S, Chen W, Murty VV, ''et al.'' |title=Chromosomal assignment of human ID1 and ID2 genes. |journal=Genomics |volume=30 |issue= 2 |pages= 385-7 |year= 1996 |pmid= 8586447 |doi= 10.1006/geno.1995.0037 }}
+*{{cite journal  | author=Mathew S, Chen W, Murty VV, ''et al.'' |title=Chromosomal assignment of human ID1 and ID2 genes. |journal=Genomics |volume=30 |issue= 2 |pages= 385–7 |year= 1996 |pmid= 8586447 |doi= 10.1006/geno.1995.0037 }}
-*{{cite journal  | author=Lasorella A, Iavarone A, Israel MA |title=Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins. |journal=Mol. Cell. Biol. |volume=16 |issue= 6 |pages= 2570-8 |year= 1996 |pmid= 8649364 |doi=  }}
+*{{cite journal  | author=Lasorella A, Iavarone A, Israel MA |title=Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins. |journal=Mol. Cell. Biol. |volume=16 |issue= 6 |pages= 2570–8 |year= 1996 |pmid= 8649364 |doi=  }}
-*{{cite journal  | author=Hara E, Hall M, Peters G |title=Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors. |journal=EMBO J. |volume=16 |issue= 2 |pages= 332-42 |year= 1997 |pmid= 9029153 |doi= 10.1093/emboj/16.2.332 }}
+*{{cite journal  | author=Hara E, Hall M, Peters G |title=Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors. |journal=EMBO J. |volume=16 |issue= 2 |pages= 332–42 |year= 1997 |pmid= 9029153 |doi= 10.1093/emboj/16.2.332 }}
-*{{cite journal  | author=Langlands K, Yin X, Anand G, Prochownik EV |title=Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. |journal=J. Biol. Chem. |volume=272 |issue= 32 |pages= 19785-93 |year= 1997 |pmid= 9242638 |doi=  }}
+*{{cite journal  | author=Langlands K, Yin X, Anand G, Prochownik EV |title=Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. |journal=J. Biol. Chem. |volume=272 |issue= 32 |pages= 19785–93 |year= 1997 |pmid= 9242638 |doi=  }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=  }}
-*{{cite journal  | author=Yates PR, Atherton GT, Deed RW, ''et al.'' |title=Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. |journal=EMBO J. |volume=18 |issue= 4 |pages= 968-76 |year= 1999 |pmid= 10022839 |doi= 10.1093/emboj/18.4.968 }}
+*{{cite journal  | author=Yates PR, Atherton GT, Deed RW, ''et al.'' |title=Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. |journal=EMBO J. |volume=18 |issue= 4 |pages= 968–76 |year= 1999 |pmid= 10022839 |doi= 10.1093/emboj/18.4.968 }}
-*{{cite journal  | author=Yokota Y, Mansouri A, Mori S, ''et al.'' |title=Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. |journal=Nature |volume=397 |issue= 6721 |pages= 702-6 |year= 1999 |pmid= 10067894 |doi= 10.1038/17812 }}
+*{{cite journal  | author=Yokota Y, Mansouri A, Mori S, ''et al.'' |title=Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. |journal=Nature |volume=397 |issue= 6721 |pages= 702–6 |year= 1999 |pmid= 10067894 |doi= 10.1038/17812 }}
-*{{cite journal  | author=Law SF, Zhang YZ, Fashena SJ, ''et al.'' |title=Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain. |journal=Exp. Cell Res. |volume=252 |issue= 1 |pages= 224-35 |year= 1999 |pmid= 10502414 |doi= 10.1006/excr.1999.4609 }}
+*{{cite journal  | author=Law SF, Zhang YZ, Fashena SJ, ''et al.'' |title=Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain. |journal=Exp. Cell Res. |volume=252 |issue= 1 |pages= 224–35 |year= 1999 |pmid= 10502414 |doi= 10.1006/excr.1999.4609 }}
-*{{cite journal  | author=Moldes M, Boizard M, Liepvre XL, ''et al.'' |title=Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes. |journal=Biochem. J. |volume=344 Pt 3 |issue=  |pages= 873-80 |year= 2000 |pmid= 10585876 |doi=  }}
+*{{cite journal  | author=Moldes M, Boizard M, Liepvre XL, ''et al.'' |title=Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes. |journal=Biochem. J. |volume=344 Pt 3 |issue=  |pages= 873–80 |year= 2000 |pmid= 10585876 |doi=  }}
-*{{cite journal  | author=Liu J, Shi W, Warburton D |title=A cysteine residue in the helix-loop-helix domain of Id2 is critical for homodimerization and function. |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 3 |pages= 1042-7 |year= 2000 |pmid= 10891368 |doi= 10.1006/bbrc.2000.3055 }}
+*{{cite journal  | author=Liu J, Shi W, Warburton D |title=A cysteine residue in the helix-loop-helix domain of Id2 is critical for homodimerization and function. |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 3 |pages= 1042–7 |year= 2000 |pmid= 10891368 |doi= 10.1006/bbrc.2000.3055 }}
-*{{cite journal  | author=Lasorella A, Noseda M, Beyna M, ''et al.'' |title=Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins. |journal=Nature |volume=407 |issue= 6804 |pages= 592-8 |year= 2000 |pmid= 11034201 |doi= 10.1038/35036504 }}
+*{{cite journal  | author=Lasorella A, Noseda M, Beyna M, ''et al.'' |title=Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins. |journal=Nature |volume=407 |issue= 6804 |pages= 592–8 |year= 2000 |pmid= 11034201 |doi= 10.1038/35036504 }}
-*{{cite journal  | author=Roberts EC, Deed RW, Inoue T, ''et al.'' |title=Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding. |journal=Mol. Cell. Biol. |volume=21 |issue= 2 |pages= 524-33 |year= 2001 |pmid= 11134340 |doi= 10.1128/MCB.21.2.524-533.2001 }}
+*{{cite journal  | author=Roberts EC, Deed RW, Inoue T, ''et al.'' |title=Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding. |journal=Mol. Cell. Biol. |volume=21 |issue= 2 |pages= 524–33 |year= 2001 |pmid= 11134340 |doi= 10.1128/MCB.21.2.524-533.2001 }}
-*{{cite journal  | author=Wang S, Sdrulla A, Johnson JE, ''et al.'' |title=A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development. |journal=Neuron |volume=29 |issue= 3 |pages= 603-14 |year= 2001 |pmid= 11301021 |doi=  }}
+*{{cite journal  | author=Wang S, Sdrulla A, Johnson JE, ''et al.'' |title=A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development. |journal=Neuron |volume=29 |issue= 3 |pages= 603–14 |year= 2001 |pmid= 11301021 |doi=  }}
-*{{cite journal  | author=Wong J, Funes-Duran M, Ahlberg J, ''et al.'' |title=Characterization of a basic helix-loop-helix protein, ABF-1: nuclear localization, transcriptional properties, and interaction with Id-2. |journal=DNA Cell Biol. |volume=20 |issue= 8 |pages= 465-71 |year= 2001 |pmid= 11560778 |doi= 10.1089/104454901316976091 }}
+*{{cite journal  | author=Wong J, Funes-Duran M, Ahlberg J, ''et al.'' |title=Characterization of a basic helix-loop-helix protein, ABF-1: nuclear localization, transcriptional properties, and interaction with Id-2. |journal=DNA Cell Biol. |volume=20 |issue= 8 |pages= 465–71 |year= 2001 |pmid= 11560778 |doi= 10.1089/104454901316976091 }}
-*{{cite journal  | author=Suzuki H, Fukunishi Y, Kagawa I, ''et al.'' |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758-65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 }}
+*{{cite journal  | author=Suzuki H, Fukunishi Y, Kagawa I, ''et al.'' |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 }}
 }}
 {{refend}}

Revision as of 20:23, 9 June 2008

References

Further reading

External links