MRNA vaccine: Difference between revisions
Content deleted Content added
Added reference for COVID-19 Tags: Visual edit Mobile edit Mobile web edit |
No edit summary Tags: Visual edit Mobile edit Mobile web edit |
||
| Line 1: | Line 1: | ||
An '''RNA vaccine''' is a novel type of [[vaccine]] which is composed of the nucleic acid [[RNA]], packaged within a [[Expression vector|vector]] such as [[Nanoparticle drug delivery|lipid nanoparticles]]<ref>{{Cite web|url=https://www.curevac.com/mrna-platform|title=mRNA Platform|last=|first=|date=|website=CureVac|url-status=live|archive-url=|archive-date=|access-date=2020-03-21}}</ref>. No RNA vaccines have yet been approved for medical use, though clinical trials are ongoing<ref>{{Cite journal|last=Zhang|first=Cuiling|last2=Maruggi|first2=Giulietta|last3=Shan|first3=Hu|last4=Li|first4=Junwei|date=2019|title=Advances in mRNA Vaccines for Infectious Diseases|url=https://www.frontiersin.org/articles/10.3389/fimmu.2019.00594/full|journal=Frontiers in Immunology|language=English|volume=10|doi=10.3389/fimmu.2019.00594|issn=1664-3224}}</ref>. A number of RNA vaccines are under development to combat the [[ |
An '''RNA vaccine''' is a novel type of [[vaccine]] which is composed of the nucleic acid [[RNA]], packaged within a [[Expression vector|vector]] such as [[Nanoparticle drug delivery|lipid nanoparticles]]<ref>{{Cite web|url=https://www.curevac.com/mrna-platform|title=mRNA Platform|last=|first=|date=|website=CureVac|url-status=live|archive-url=|archive-date=|access-date=2020-03-21}}</ref>. No RNA vaccines have yet been approved for medical use, though clinical trials are ongoing<ref>{{Cite journal|last=Zhang|first=Cuiling|last2=Maruggi|first2=Giulietta|last3=Shan|first3=Hu|last4=Li|first4=Junwei|date=2019|title=Advances in mRNA Vaccines for Infectious Diseases|url=https://www.frontiersin.org/articles/10.3389/fimmu.2019.00594/full|journal=Frontiers in Immunology|language=English|volume=10|doi=10.3389/fimmu.2019.00594|issn=1664-3224}}</ref>. A number of RNA vaccines are under development to combat the [[2019–20 coronavirus pandemic]]<ref>{{Cite web|url=https://www.statnews.com/2020/03/19/an-updated-guide-to-the-coronavirus-drugs-and-vaccines-in-development/|title=An updated guide to the coronavirus drugs and vaccines in development|date=2020-03-19|website=STAT|language=en-US|access-date=2020-03-21}}</ref>. |
||
Just like normal vaccines, RNA vaccines are intended to induce the production of [[Antibody|antibodies]] which will bind to potential [[Pathogen|pathogens]]. This is accomplished when the RNA from the vaccine (a [[messenger RNA]]) is delivered into [[Cell (biology)|cells]] in the body, which then produce [[Protein|proteins]] that resemble or are identical to proteins from the pathogen. These proteins are then used by the body’s [[adaptive immune system]] to produce antibodies against the pathogen, causing future protection from the pathogen.<ref>{{cite web |last1=Hubaud |first1=Alexis |title=RNA vaccines: a novel technology to prevent and treat disease |url=http://sitn.hms.harvard.edu/flash/2015/rna-vaccines-a-novel-technology-to-prevent-and-treat-disease/ |website=sitn.hms.harvard.edu |publisher=Harvard University |accessdate=17 February 2020}}</ref> |
Just like normal vaccines, RNA vaccines are intended to induce the production of [[Antibody|antibodies]] which will bind to potential [[Pathogen|pathogens]]. This is accomplished when the RNA from the vaccine (a [[messenger RNA]]) is delivered into [[Cell (biology)|cells]] in the body, which then produce [[Protein|proteins]] that resemble or are identical to proteins from the pathogen. These proteins are then used by the body’s [[adaptive immune system]] to produce antibodies against the pathogen, causing future protection from the pathogen.<ref>{{cite web |last1=Hubaud |first1=Alexis |title=RNA vaccines: a novel technology to prevent and treat disease |url=http://sitn.hms.harvard.edu/flash/2015/rna-vaccines-a-novel-technology-to-prevent-and-treat-disease/ |website=sitn.hms.harvard.edu |publisher=Harvard University |accessdate=17 February 2020}}</ref> |
||
Revision as of 04:00, 21 March 2020
An RNA vaccine is a novel type of vaccine which is composed of the nucleic acid RNA, packaged within a vector such as lipid nanoparticles[1]. No RNA vaccines have yet been approved for medical use, though clinical trials are ongoing[2]. A number of RNA vaccines are under development to combat the 2019–20 coronavirus pandemic[3].
Just like normal vaccines, RNA vaccines are intended to induce the production of antibodies which will bind to potential pathogens. This is accomplished when the RNA from the vaccine (a messenger RNA) is delivered into cells in the body, which then produce proteins that resemble or are identical to proteins from the pathogen. These proteins are then used by the body’s adaptive immune system to produce antibodies against the pathogen, causing future protection from the pathogen.[4]
See also
References
- ^ "mRNA Platform". CureVac. Retrieved 2020-03-21.
{{cite web}}: CS1 maint: url-status (link) - ^ Zhang, Cuiling; Maruggi, Giulietta; Shan, Hu; Li, Junwei (2019). "Advances in mRNA Vaccines for Infectious Diseases". Frontiers in Immunology. 10. doi:10.3389/fimmu.2019.00594. ISSN 1664-3224.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ "An updated guide to the coronavirus drugs and vaccines in development". STAT. 2020-03-19. Retrieved 2020-03-21.
- ^ Hubaud, Alexis. "RNA vaccines: a novel technology to prevent and treat disease". sitn.hms.harvard.edu. Harvard University. Retrieved 17 February 2020.